First, I want to say this is just a theory.
" Because inflammatory changes have been associated with the diagnosis of BPH13 as well as increasing age,14 we investigated and found that tumor necrosis factor α (TNF-α), NF-κB, and IL-6 regulate DNMT1 and subsequent methylation of the SRD5A2 promoter region. In addition, we show that SRD5A2 promoter methylation and reduced protein expression are associated closely with increasing age in both human and mouse tissues."
Lets say SSRIs/Fin led to oxidative stress and inflammation cascade in several tissues, like here: https://www.hindawi.com/journals/omcl/2018/7196142/
Then that would lead to silencing of SRD5A2 in various tissues (assumption: SRD5A2 is regulated by inflammation just like in prostata tissue). Meaning, silencing of 5 alpha reductase in the brain, leading to low neurosteroids and neuroinflammation, silencing of 5 alpha reductase in other tissues.
This methylation of SRD5A2 gene promoter region in prostata tissue happens gradually as we age. It was reversed by downregulation of DNA methyltransferase 1 expression, which is regulated by TNF-a, Nf-kb and IL-6.
Maybe the cure is surpressing TNF-a, Nf-kb and IL-6 for long enough and potent enough? Silencing of SRD5A2 in aging happens gradually… Maybe by reducing inflammation and oxidative stress while avoiding all triggers (even exercise can trigger inflammation) … one could gradually demethylate SRD5A2
I’ve seen multiple stories now, doing just that… focusing on anti inflammation diet/oxidative stress relieving for long enough… sodium butyrate, keto diet, etc… also fit in that picture.
To me it seems these post drug syndromes are almost artificial aging induced by oxidative stress/inflammation + epigenetic changes + neuroinflammation.
I will now focus on downregulating TNF-a over a long time period, for that I will use diet, supplements, and peptides.