Retinoids in Mammalian Reproduction, with an Initial Scoping Effort to Identify Regulatory Methods

General Discussion
#1

The Baylor study could read pretty similar with Accutane, just replace Androgens with Retinoids.

This Nordic report builds on ideas brought forward in the OECD Detailed Review Paper (DRP) 178 on screening and testing methods and endpoints for evaluating endocrine disruptors. It was identified that the retinoid system is not presently included in any OECD test guideline, and that it is urgent to cover this knowledge gap.The present TemaNord report is a contribution to an upcoming OECD DRP on retinoids. An overview of retinoid biology in female and male reproduction is presented. The report identifies that, in general, there is a lack of studies investigating effects of chemicals on reproduction, while simultaneously examining effects on retinoid related parameters. This is a major data gap. However, selected in vitro and/or in silico retinoid-related endpoints, presented in this report, could possibly be part of a broader screening test battery aimed at reproductive toxicity.

    1. Introduction to the retinoid system
    1. Formation of female and male reproductive organs, and the role of retinoids
    1. Germ cells, meiosis and the role of retinoids
    1. Female reproductive organ development, function and health and the role of retinoids
    1. Male reproductive organ development, function and health, and the role of retinoids
    1. Impact on female and male reproduction by compounds acting via the retinoid system
    1. Potential adverse outcome pathways in female and male reproduction
    1. Initial scoping effort: assays and endpoints for effects of chemicals on female and male reproduction via the retinoid system
    1. Concluding remarks