Retinoid Regulation of Ocular Surface Innate Inflammation

Obviously this thought process could extend well beyond healthy vision.

Retinoid Regulation of Ocular Surface Innate Inflammation

Keynotes
Retinoids are essential for maintaining a healthy, well-lubricated ocular surface and have immunomodulatory effects in the conjunctiva that are mediated in part via RXR-α signaling. Perturbation of the homeostatic retinoid axis could potentiate inflammation on the ocular surface.

Vitamin A is essential for maintaining a lubricated uninflamed ocular surface and clear cornea.

Also another possible mechanism,

The effects of vitamin A compounds on hyaluronic acid released from cultured rabbit corneal epithelial cells and keratocytes

A role of vitamin A in the synthesis of hyaluronic acid by skin cells is well known.
vitamin A also stimulates the release of hyaluronic acid from cultured rabbit corneal epithelial cells and keratocytes.

Interesting, I guess we can’t really rule out RA either since a fasting environment has helped many, but the key initial component may still be retinol, not the conversion to RA.

So many body components need vitamin A, Interesting but not surprised either.

Read vitamin A can shut down the immune system yet is considered chemotherapy to some degree by the medical community. Got any thoughts on This?