Retinoic Acid's extensive effects on Lipid and protein metabolism

General Discussion
#1

I didnt know this until recently, so your talking overall effects on growth and development.
Notice thermogenesis.

Lipid metabolism in mammalian tissues and its control by retinoic acid

Vitamin A Deficiency Increases Protein Catabolism and Induces Urea Cycle Enzymes in Rats

https://academic.oup.com/jn/article/140/4/792/4743291

1 Like
#2

Also when we undergo iso course, we are supposed to take regular LFTs. so iso definitely has effects on lipid profile.

#3

Here’s another surprising one. Ive talked about a possible blood disorder as well in all of this.
I did test positive once for what could be considered antiphospholipid syndrome, also known as thick or sticky blood disorder.
Amongst vitamin A and its derivatives, retinoic acid showed the highest inhibition of both the forms of thrombin.

Inhibition of thrombin, an unexplored function of retinoic acid

https://www.sciencedirect.com/science/article/pii/S2405580818302838

#4

Retinoic Acid basically preventing metabolic syndrome and i remember a study stating isotrentoin speeding up/inducing metabolic syndrome.

It might be like needing something that the body stops using. You thinking along the same lines?

#5

Im thinking of increasing the expression of the raldh2 enzyme that facilitates the conversion of retinol to retinoic acid. One thought.

One quick random example,

ALDH1A2 (RALDH2) genetic variation in human congenital …

bmcmedgenet.biomedcentral.com › articles
](https://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2350-10-113)

Nov 3, 2009 - Since conversion of retinaldehyde to RA by retinaldehyde dehydrogenase type II (ALDH1A2, a.k.a RALDH2 ) is critical for cardiac development, …

by M Pavan - ‎2009 - ‎Cited by 35 - ‎Related articles

heres another,

Retinaldehyde Dehydrogenase 2 (RALDH2)-mediated …

pubmed.ncbi.nlm.nih.gov › …
](https://pubmed.ncbi.nlm.nih.gov/16368932)

Retinaldehyde Dehydrogenase 2 ( RALDH2 )-mediated Retinoic Acid Synthesis Regulates Early Mouse Embryonic Forebrain Development by Controlling FGF …

by V Ribes - ‎2006 - ‎Cited by 136 - ‎Related articles

last one,
The retinoic acid synthesis in testes is catalyzed primarily by the RALDH2 enzyme.

#6

I take fluoxetine to prevent breakdown of RA but studies also state patients on fluoxetine get fatty liver, which I can’t make sense of, which I am concerned about.