Retinoic Acid and Affective Disorders: The Evidence for an Association

This could be an example of why you take a step back and look at everything. How do you recover from a toxic drug exposure? This could almost be looked at similar to being a stroke or burn victim. What can be done to accelerate recovery?

“In the case of patients reported to the Norwegian Medicines Agency, single photon emission computed tomography (SPECT) of the brain was performed in 15 cases who reported lasting neurological symptoms. Altered brain function was seen in all cases involving altered or reduced frontal lobe blood flow.173 Ten of these patients were evaluated to have organic brain damage.”

Isotretinoin (13- cis -retinoic acid, or 13- cis -RA) (Accutane), approved by the FDA for the treatment of acne, carries a black box warning related to the risk of depression, suicide, and psychosis. Retinoic acid (RA), the active form of vitamin A, regulates gene expression in the brain, and isotretinoin is its 13- cis isomer. Retinoids represent a group of compounds derived from vitamin A that perform a large variety of functions in many systems, in particular the CNS, and abnormal retinoid levels can have neurological effects. Although infrequent, proper recognition and treatment of psychiatric side effects in acne patients is critical given the risk of death and disability. This paper reviews the evidence for a relationship between isotretinoin, depression and suicidality.