In August of 2019 I had PFS but hadn’t fully realized it yet. I knew something was up with my skin though, and so I dermarolled weekly to induce collagen. Whenever I would apply retin-a after dermarolling, a few hours after, skin still open, I would feel significantly better in the days following. Not just in the skin where I dermarolled, but my hair would also have collagen return to it. In hindsight though, name a PFS symptom, it got better, I remember feeling much more emotional and euphoric feelings in response to music, etc. I remember fapping and seeing hair fall out during that time, something that does not happen in baseline PFS.
I believe this to be another example of the on-off effect that many have, where they take an anti-androgenic substance and feel better in the following days. In fact, that behavior parallels the “crash” we get after quitting our drugs, just on a much smaller level.