I want to use tretinoin for topical anti-acne treatment. Is it safe? Because accutane can cause sexual side effects as well but I doubt the absorption via skin will be high enough to cause any amount of substantial serum levels.
I personally use topical tretinoin; have been for 15 years. I don’t think the concentration is high enough to cause problems. I don’t think it is like finasteride where tiny amounts can have big effects. Also you already have retinoic acid naturally since it is a metabolite of vitamin A. Plus I am already fucked with zero libido so I don’t care.
Personally I wouldn’t use anything even topical also stay away from anything with azalic acid its a 5AR inhibitor, I crashed using a topical shampoo and would have never thought it would damage me as much as it has.
Can you name the shampoo?
Regenepure DR that’s what got me here I’m really messed up from that stuff, it contains ketokonzale and saw palmetto I used it 3 times a week for 3 years worst mistake of my life.
In August of 2019 I had PFS but hadn’t fully realized it yet. I knew something was up with my skin though, and so I dermarolled weekly to induce collagen. Whenever I would apply retin-a after dermarolling, a few hours after, skin still open, I would feel significantly better in the days following. Not just in the skin where I dermarolled, but my hair would also have collagen return to it. In hindsight though, name a PFS symptom, it got better, I remember feeling much more emotional and euphoric feelings in response to music, etc. I remember fapping and seeing hair fall out during that time, something that does not happen in baseline PFS.
I believe this to be another example of the on-off effect that many have, where they take an anti-androgenic substance and feel better in the following days. In fact, that behavior parallels the “crash” we get after quitting our drugs, just on a much smaller level.
Iam currently using Retin-a aka tretinoin on my skin and I am quite sure that my sexual function gotten worse. The only question is if its because of that.
I was cured 90%, now Iam back to 60-70% in that state. We will see. I have acne und it seems that all medications that reduce acne are acutally 5ARs, azelaic acid, retinoids, etc. I was using adapalen (3rd generation retinoid) the enitre last 6 months and I think it decreased my baseline.
For acne, take cold showers and see what that does.
If acne does not improve then I guess your could try glycolic acid, I read a study that says it has no anti androgenic activity.
I also notice 5ars crash me, I’ve gotten worsened temporarily by deodorant and cologne.
Iam still not sure whether tretinoin has a negative effet on me. I was using it everyotherday. It is very hard to distinguish between diet, and other factors. I will now pause the treatment and see if I get back to my baseline because now I kinda have a fin dick again.
@hopeless94 any update??
I use tretinoin 0.1% and it does not affect me in any negative way.