Regenepure DR that’s what got me here I’m really messed up from that stuff, it contains ketokonzale and saw palmetto I used it 3 times a week for 3 years worst mistake of my life.
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Thanks Aaron.
In August of 2019 I had PFS but hadn’t fully realized it yet. I knew something was up with my skin though, and so I dermarolled weekly to induce collagen. Whenever I would apply retin-a after dermarolling, a few hours after, skin still open, I would feel significantly better in the days following. Not just in the skin where I dermarolled, but my hair would also have collagen return to it. In hindsight though, name a PFS symptom, it got better, I remember feeling much more emotional and euphoric feelings in response to music, etc. I remember fapping and seeing hair fall out during that time, something that does not happen in baseline PFS.
I believe this to be another example of the on-off effect that many have, where they take an anti-androgenic substance and feel better in the following days. In fact, that behavior parallels the “crash” we get after quitting our drugs, just on a much smaller level.
Iam currently using Retin-a aka tretinoin on my skin and I am quite sure that my sexual function gotten worse. The only question is if its because of that.
I was cured 90%, now Iam back to 60-70% in that state. We will see. I have acne und it seems that all medications that reduce acne are acutally 5ARs, azelaic acid, retinoids, etc. I was using adapalen (3rd generation retinoid) the enitre last 6 months and I think it decreased my baseline.
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For acne, take cold showers and see what that does.
If acne does not improve then I guess your could try glycolic acid, I read a study that says it has no anti androgenic activity.
I also notice 5ars crash me, I’ve gotten worsened temporarily by deodorant and cologne.
little update:
Iam still not sure whether tretinoin has a negative effet on me. I was using it everyotherday. It is very hard to distinguish between diet, and other factors. I will now pause the treatment and see if I get back to my baseline because now I kinda have a fin dick again.
I use tretinoin 0.1% and it does not affect me in any negative way.
Still not sure. Iam using 0.1% adapalene at the moment. I have moderate to severe acne and obviously I dont wanna hop on isotretinoin as someone who developed PFS.
I did the research and the systemic absorption from topical retinoids seems neglible. But there are people who reported harm from topical agents. Therefore I will be switching to trifarotene, which has binds only to those retinoid receptors in the skin, whereas most other retinoids also bind to RAR-beta which is also present in the prostate. I dont know how relevant that is, but I want to make sure.
Stop putting value in how you look. Stop seeking medication to look “better”. Remember, that’s what got you on this forum in the first place.
For acne, avoid dairy, avoid stress (Wim Hof breathing and meditation are good for this), and do cold showers a few times a week. This will improve your acne in the long term. Tretinoin only improves it in the short term.
No extremely rare and not official reported side effects put me here.
Tretinoin works as long as you use it.
I tried retinol for 6 months since i have rly bad issue with facial skin( sleeping wrinkles all over whole face…) it worsened my skin massivily. My second biggest mistake. Id not fuck with it
There is a member of one of the post-Accutane groups on facebook who says she got “PAS” after using Retin-A or some other generic topical tretinoin product.
It’s worth considering that 38% of tretinoin was converted into isotretinoin (Accutane) by UV light in a study using cadaver skin and this percentage may be much higher in live skin due to active isomerase enzyme activity.
Lehman, Paul A., and Andrew M. Malany. “Evidence for Percutaneous Absorption of Isotretinoin from the Photo-Isomerization of Topical Tretinoin.” Journal of Investigative Dermatology , vol. 93, no. 5, Nov. 1989, pp. 595–99. ScienceDirect , https://doi.org/10.1111/1523-1747.ep12319721.
…A link to full text doesn’t appear to be available.
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I was using 0.1% adapalen since late december and it cleared pretty much my acne. There are not many medical interventions for acne, either its retinoids or anti-androgen substances like azelaic acid. To my mind only topical antibiotic and BPO are seem to be completly safe and have decent efficacy.
Although I didnt notice any changed in sexual functions and I think there might be an influence. So I have stopped for over one week and now Iam using it again to see if it causing any problems.
Nonetheless I will probaly stop regardless of it.
The thing is, retinoids ARE anti-androgenic at the doses/concentrations used therapeutically for skin conditions.
This is true of isotretinoin, tretinoin, alitretinoin, and the carotenoid, astaxanthin.
Simply being an agonist of retinoic acid receptors exerts an anti-androgenic effect via upregulation of FOXO1.
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Yeah but to what extend? Systemic absorption seems very low, unlikely that topical retinoids result in hormonal changes that are even detectable. This is just another PFS mystery that we are hypersensitive to anti-androgens.
my last hope is trifarotene. its an retinoid that was designed to have a low systemic effect. It only binds onto one specific retinoid receptor.
Thank you for bringing attention to this. I’ve been using azelaic acid for a month and have already noticed worsening of my condition. I was unaware of possible connection. I’m also searching for a good anti-acne treatment that won’t make my condition even worse.
Azelaic acid is highly anti-androgenic.
Combination of clindamycin and benzolperoxide seems to be the most effective treatment while having no anti-androgenic effect. You can also try AHA-Peelings.
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Thanks a lot. Have you already tried trifarotene? I haven’t heard about it before but now I have some hopes too.
Nope in theory it has the highest chance of not getting into the system.
Little Update btw: Applied Adapalen yesterday evening and actually feeling better. Not so much sexual that was fine before but more mental. Better mood and emotion. I also feeling my body more. So yes it seems to be interfering with it. not unsual that anti androgens male bwtter in the short term.
Iam not quite confident about the causation because it was only one application. I dont know how I can even test if it has a bad effect on me. I mean maybe the effects take several days of usage or weeks to show up. I started in December 2021 and didnt notice much maybe more mental side effects.
Thats the reason why I didnt give a fuck about thinking of every food and substance that could possibly have anti androgenic effects. Its too much and made me neurotic.
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