I just posted this under another topic. However seeing as this a topic in regards to epigenetic modulation I thought I’d post just one of the pieces of research I have found:
D’Addario, C., Di Francesco, A., Pucci, M., Finazzi Agrò, A., & Maccarrone, M. (2013). Epigenetic mechanisms and endocannabinoid signalling. FEBS Journal,280(9), 1905-1917.
• It has also been observed that THC and cannabinol can (a) activate the ERK-MAPK cascade, a crucial event for gene activation during mitosis induction, and (b) inhibit gap-junction intercellular communication, required to relieve growth suppression of cells .[/u]
• Altogether, these results show a new activity of eCB’s as transcriptional repressors via epigenetic mechanisms and in, in the search of drugs able to reverse methylation abnormalities, they suggest a possible exploitation of eCB signaling in human diseases where DNA methylation is downregulated.
• eCB-mediated transcription involves coordinated interactions of CB receptors with acetylases and deacetylases, methylases and demethylases. In addition, eCBs have the potential to trigger extranuclear signaling that activates several kinase cascades, which either directly modify histone tails or indirectly influence functions and/or recruitment of histone-modifying enzymes.
• Indeed, epigenetic alterations are reversible and specific interventions that target different epigenetic pathways might have a major impact on health problems, eventually providing a new avenue for innovative therapeutic approaches.
Seeing as I’ve only posted a small part, I’ll point out that stimulation of the endocannabinoid system was done with THC and CBD. 2 cannabinoids found in cannabis.