I’m on TRT and getting diminishing returns, and I think it may be due to a reflexive increase in SHBG. PFS is either causing me to overproduce SHBG in response to testosterone and DHT, or there’s something in the SHBG that blocks off the androgen receptors. This would be why I had no lasting improvement from Andractim or DHT-derived SHBG inhibitors either, because my body just pumps out more SHBG in response to the inhibitor.
I read that eating lots of sugar can reduce SHBG, by causing the body to produce more insulin (which binds the stuff.) Less unbound SHBG = less of the crap that’s plugging up the androgen receptors. If PFS causes SHBG (or the receptor-blocking crud that propecia put in it) to rise in response to DHT, then Proviron wouldn’t have a lasting benefit. But insulin is not DHT.
Has anyone tried this, and what happened?
PS Is there a point at which SHBG production “runs out of gas,” i.e, cannot keep producing enough to maintain a high level of SHBG, and falls back down to a lower level? Or can the body produce an infinite amount of SHBG for an indefinite amount of time?