Recreational drugs induced sexual dysfunction

[Knifli]

Do you guys believe that a sexual dysfunction induced by drugs like MDMA, LSD etc… is also a endocrine disruption, and ‘the same’ as PFS/PSSD/PAS?

[Cooper]

Mdma causes it, but not lsd. I don’t use them, just research information.

[Knifli]

There are some anecdotal reports that it is possible from LSD and shrooms. Also some people got PSSD like symptoms from 5-htp supplementation so i guess all things that elevate serotonin can cause something like PSSD.

[Cooper]

In our forum, few people recovered with using Shrooms. They were PFS patients if i remember correctly.

[Knifli]

Yeah on the PSSD forum some people also got improvements with shrooms and i think there was also a recovery with MDMA/Shroom combo.

Anyway, i’m just wondering if people who have PSSD/PFS/etc…-like problems because of recreational drugs have the same ‘syndrome’ as we have.

[axolotl]

@Knifli

i guess all things that elevate serotonin can cause something like PSSD.

It’s certainly plausible - I discussed the possibility of this based on a very interesting and thorough study here:

Serotonin regulates prostate growth through androgen receptor modulation

Recently I reviewed @Rb26dett’s case after he shared his experience. Considering a demonstrable property of antiandrogenic action amongst substances causing members to experience PFS, I had a look for evidence that 5-HT is capable of a notable downregulatory effect on the AR. The following 2017 study explored this in detail, with strong evidence both in vitro and in vivo: https://www.nature.com/articles/s41598-017-15832-5 Serotonin regulates prostate growth through androgen receptor modulatio…

[Cooper]

So, do you have any possible treatment theories? Should we try cycling shrooms? Im not a pssd sufferer. Maybe it only works for PSSD people. Not for PAS (me) or PFS.

[Invictus]

I have PFS and feel incredible on shrooms. But the day after I always get depression so I stopped using shrooms.

But also healthy people report depression after a LSD/shroom trip so I guess its normal and not PFS related .

[Knifli]

I’m not that knowlegdeable myself, maybe someone else with more knowledge can jump in but here are some intresting threads from the PSSD forum.

(Hypothesis why shrooms could cure someone)

“Blunted HPA axis though antidepressant-induced upregulation of GR. Less cortisol -> less glutamate -> LTP disruption. Basically, you restored LTP with psilocybin and you reaped the benefits.”

http://www.pssdforum.com/viewtopic.php?f=14&t=179&start=50

http://www.pssdforum.com/viewtopic.php?f=22&t=2785&hilit=Psilocybin

http://www.pssdforum.com/viewtopic.php?f=22&t=2785&p=26917&hilit=Psilocybin#p26917

[joetz]

Are they microdosing or just taking a giant hit? Microdosing seems to be the rage now

I’ve seen dozens of videos you YouTube about it.

Microdosing mushrooms and lsd seems to be the new thing in Silicon Valley