random theory by an idiot

General Discussion
#1

Hi yall im new to this disease and I dont have any sort of education in biology except for one microbiology class. I’ve been trying to get a better understanding of this drug (poison) and how it works. I’ve also been trying to get familiar with all of the biological terminology of hormones and things. Anyways ive been reading some articles and linked together a few things that I guess creates some sort of guess at what has happened to us. I could be completely wrong and be making no sense lol but here it is:

I read from rxlist.com under the mechanism of action of propecia that inhibition of the 5ar enzymes is accompanied by adduct formation of NADP+.rxlist.com/propecia-drug/cli … cology.htm

i dont know what adduct formation means but apparently the NADP+ system (according to wikipedia) is responsible for generating free radicals in immune cells to destroy pathogens via respiratory burst. This is source of reducing equivalents for Cytochrome P450 hydroxylation of steroids, alcohols, and drugs. en.wikipedia.org/wiki/Nicotinami … _functions

Also from wikipedia, Cytochrome P450 enzymes are found in most tissues in the body (think facial changes, wrinkly hands, skin, etc.) and these enzymes play important roles in hormone synthesis and breakdown including testosterone, estrogen, and metabolization. en.wikipedia.org/wiki/Cytochrome_P450

So essentially, I’m saying that finasteride messes with our nadph formation, which leads to less free radicals in immune cells, which then leads to less Cytochrome P450 enzymes, which results in our bodies being unable to properly breakdown testosterone and estrogen, which gives us our symptoms. However the testosterone and estrogen would still exist, which is why our lab results don’t show abnormal levels of these hormones.

Well this may just be rubbish and if so feel free to laugh at me lol. Im in college now and although im a bio major i havent really gotten to any of the non-core classes. I just hate this disease so much, I’ve had it for 7 days and feel like my life will never be the same. I’m already forgetting what it feels like to be happy, or aroused, or excited, or worry-free. I’ve never woken up in the middle of the night and had a panic attack before taking this drug. I just want to go back to the way things used to be and I really appreciate everyone here who is working to find a solution.

#2

I’m just very fuckin sad to see that people are starting to take this poison just a month ago or maybe just now, while i’m typing this… Man… can’t you just google out ‘propecia side effects’… Or type it on youtube… You’ll find clips that will scare the shit out of you. When i started taking this damn pill, situation was pretty different and much more vague. I knew there are side effects, but i don’t remember seeing any info it could be permanent… Not that i researched it properly, but certainly there is more data now…

Also, maybe you haven’t figured it out yet, but this forum is full of theories of all kind… In our desperation i guess we need at least something to cling on. But the main problem is that we have not one medical expert here who could give us any answer or explanation, probably because they ain’t dumb (misinformed) enough to take 5ar inhibitor in the first place…

#3

Let me refer you to this thread, so that you get a feel for what this forum is about:

viewtopic.php?f=1&t=10088

Only participate in a study when side effects dont disappear after months passing. If that happens, you know what to do after reading the thread above.

#4

PVDL- shut your mouth you dumb ass, you are so annoying

He actually has hit on something that a journal article just published regarding finasteride and development of Melasma. Note where the authors comment on what might be happening

link.springer.com/article/10.100 … 014-1466-5

#5

The guy above is the psychopath of the forum. He is recovered aparently, but stays on this forum because he gets a kick out of the suffering. Dont listen to him.

#6

Read the article you backward German retard. The auithors theorize a change in the psychotrome P450 system, same as the original poster had mentioned.

#7

You think that is bad… back in the late 90’s early 2000’s there wasn’t anything, that old Yahoo group formed in 2003. Who knows how many people got it early on and just killed themselves not even knowing what was causing their depression.

#8

I didnt comment on his theory you nut. I just said that a summary of what is going on on this forum can be found at the link.

Never did I comment on this theory.

That you validate his theory with a link to scientific research, which you refuse to participate in and even mock, is absurd.

But I guess you are recovered already, so who cares. You just love bathing in the misery and getting people rilled up even more.

Since when is participating in studies and calling on other to do so, backward? Isnt science modern, and homebrew (which you love to defend) medieval.

Guess not in Finatruths world. Gotta love this retard. He check mates himself constantly.

#9

That I validate his theory to a study I refuse to participate? What the fuck are you talking about? I posted a link of a case report where a bunch of dermatologists theorized exactly what the poster theorized. You make no sense.

#10

Of course I make sense.

On the one hand you mock me, for propagating the view that people have to participate in studies. On the other hand you go on the attack by citing a study on finasteride. To me you just have gone full retard.

You mock me for supporting the work of scientists, and then use the work of scientists to go on the attack.

#11

I never mocked you, I called you a cunty little whinny bitch who says he is going to do something but won’t participate. The studies are important. So when are you comming to do the study? Your not, again, because you are a little cry baby bitch

#12

^

FORUM RULES:

No slandering of group members
Do not post anything which will be offensive to other members
Disagreements are allowed, but please present your facts, cite your sources and refrain from insulting one another.
If you have studies you can reference please include them in your post
Please keep this group as professional as possible

#13

Harissoff, you will do yourself a lot of good if you just go into your settings and put “pvdl” on ignore. He means good (just wants more people to focus on the studies), but he doesnt realize that he turns everybody off big time.

As for the theory, even if it isnt the cause of PFS…I thank you for bringing up yet another mechanism in which finasteride screws with our biological metabolism. Finasteride also severely depletes nuerosteroids and Glutathione as well.

Life Extention Magazine recently had an article on NADP+. I think if you want to test your theory, you might try Nicotinamide. Trying that compound should not make you ineligible for any of the studies in the future if you go that route (I encourage you to).

lef.org/Magazine/2015/1/Next … de/Page-01

#14

… Truly sad to have idiots like you on board.

#15

False, I am one of the few people who refuse to participate in homebrew bullshit. The guy above loves to waste time.

We have a major problem here; lack of study participation. And he wants everyone to block me, even though I am the only one who focuses on this issue. Of course I turn lots of homebrewers off big time. They dont want to hear about studies and the possibility that their homebrew bullshit wont get them anywhere. You sound like an patronizing asshole.

Insane!

Basically there is a major study going on, and they are only looking for about to dozen PFS participants. They are still not filled, even though they have been looking for participants since October 2013. Instead of supporting me big time, he calls for silencing me via putting me on ignore. Its the worst thing he could do. People need to get a kick in their behind.

#16

It’s reading threads like this one why I very rarely post anymore and Im so glad. I prefer to browse occasionally nowadays

Some people never change!!!

Hilarious :laughing:

Happy New Year

#17

Hey Paul, happy new year! Hope you are doing well.

#18

This is why nobody take you serious. You completely make up a bunch of random nonsense. How am I wasting time? I am not eligible for the studies because I used Saw Palmetto. I still donate monthly and encourage people who are eligible to participate in the studies. In the mean time, I am not just going to sit back and do nothing at all. I am happy I have “homebrewed”, because I have managed to DRAMATICALLY improve my condition by doing so. Maybe I should have just sat back and done nothing so that I could still be in the completely shitty state I was previously in. That is what you want right?

As far as lack of study participation, that is most likely on Baylor themselves. The Bigham study had no issue finding 61 participants. The Italian studies got all their participants. I’ve seen multiple posters here say that they tried to contact Baylor and received no response. So instead of verbally harassing all the PFS guys here and being a keyboard warrior maybe you should try to help Baylor figure out what their communication issue is and why they are not able to find participants when they other studies are already done with that phase.

I did not tell him to ignore your message of how important the studies are. I told him to ignore you in general because you are annoying and all you do is harass people. You are in effect, a negative asset for the PFS Foundation.

#19

I have been in contact with Baylor. Yes you have to go via the foundation if they dont respond, but a little effort is enough to get in contact. Its on us to get it filled quickly.

They only need like two dozen PFS guys, and they are looking since October 2013. Nothing can explain this, except lackluster participation. This homebrew insanity carousel is distracting from this goal (quickly filling the spots for the study). We are the ones fucked here, so we have to literally harass baylor to get the study done quickly.

If homebrew is such a success story like you claim, why isnt there any treatment available. Lets be honest here, lots of guys are wasting money and time on treatments that might even make them worse off. Nobody seems to care that the study is taking ages to fill. I cant comprehend this complacency, especially from the US guys.

How is anyone going to take this community seriously, when they cant get their asses off the couch and get 20 peole to sign up. If you are not eligible you should be spamming this forum until the study is filled. Simple as that. You should lobby anyone you know, who has serious PFS and lives in the US to sign up.

#20

man pvld… Is this really the first impression you want to give to someone who just joined the forum. He provided a thoughtful post, and you’re going off on everyone destroying the thread? NO ONE is going to listen to you with your disrespectful attitude.

This is no way to go through life.