I have been reading about the rare genetic disease called Androgen Insensitivity Syndrome (AIS). From what I have read, it only effects males. Women may carry the faulty gene but don’t develop serious phenotypical abnormalities.
AIS patients have dysfunctional androgen receptors. If faulty androgen receptors are also the cause of PFS, how can women be effected by the condition?
See relevant information about AIS below:
Androgen insensitivity syndrome (AIS) is a difference in sex development involving hormonal resistance due to androgen receptor dysfunction.
It affects 1 in 20,000 to 64,000 XY (karyotypically male) births. The condition results in the partial or complete inability of cells to respond to androgens. This unresponsiveness can impair or prevent the development of male genitals, as well as impairing or preventing the development of male secondary sexual characteristics at puberty. It does not significantly impair female genital or sexual development. The insensitivity to androgens is therefore clinically significant only when it occurs in genetic males, (i.e. individuals with a Y-chromosome, or more specifically, an SRY gene).