Question about hormones

Symptoms
#1

So question some of yall say that they have PFS but don’t have any hormone change, but claim they have muscle waste, stomach issues, and brain fog. So how is it that you have these issues?

#2

The cause of PFS is likely at the receptor level, or to do with hormone signalling. As a result, someone could have perfect hormone levels but still have the issues you described, given that those respective receptors have issues.

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#3

But then you body would be in worse shape then just some ED. Your body would be able to function correctly at all

#4

  • Many of us have multi-system symptoms.

  • We also have evidence that the effects of PFS are specific to certain tissues, and not others.

  • The PFS patients studied so far generally have normal levels of circulating T and DHT.

  • Significant differences were found between the levels of androgen receptor and its respective RNA in PFS patients compared to controls.

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#5

#6

And fo you mind showing me a article on that?

#7

Do you mind telling me what symptoms you have?

#8

@Kelld56

If you want to know more about documented research you can take a look at the following page:

Many of your questions have answers that are readily available, please use google and the search function instead of depending on others to give it to you.

#9

But what symdo you have?

#10

Normal hormone levels in PFS patients:

Irwig, Michael S. “Androgen Levels and Semen Parameters Among Former Users of Finasteride With Persistent Sexual Adverse Effects.” JAMA Dermatology, vol. 150, no. 12, Dec. 2014, pp. 1361–63. archderm.jamanetwork.com, https://doi.org/10.1001/jamadermatol.2014.1830.

Normal levels of T and DHT in blood of PFS patients, but altered levels of neuro-hormones:

Melcangi, Roberto Cosimo, et al. “Neuroactive Steroid Levels and Psychiatric and Andrological Features in Post-Finasteride Patients.” The Journal of Steroid Biochemistry and Molecular Biology. ScienceDirect, https://doi.org/10.1016/j.jsbmb.2017.04.003. Accessed 17 Apr. 2017.

Abnormal gene expression in multiple pathways, including androgen receptor overexpression, in penile skin samples taken from PFS patients:

Howell, Skyler, et al. “Differential Gene Expression in Post-Finasteride Syndrome Patients.” The Journal of Sexual Medicine, vol. 18, no. 9, Sept. 2021, pp. 1479–90. Europe PMC, https://doi.org/10.1016/j.jsxm.2021.05.009.

Overexpression of androgen receptor in PFS patients:
Loreto, Carla Di, et al. “Immunohistochemical Evaluation of Androgen Receptor and Nerve Structure Density in Human Prepuce from Patients with Persistent Sexual Side Effects after Finasteride Use for Androgenetic Alopecia.” PLOS ONE, vol. 9, no. 6, June 2014, p. e100237. www.plosone.org, https://doi.org/10.1371/journal.pone.0100237.

Like @Wintermoon said, you’ll have to do further investigation into the literature about PFS on your own.

Every member is also expected to have a member story in the Member Story Category, where our symptoms and general experience with a post-drug syndrome is discussed.

I approved your membership not realizing it hasn’t even been a month since your last exposure to finasteride. We generally don’t approve memberships for those who have been experiencing post-drug side-effects for less than 3 months because the majority recover from these lingering side-effects in that time, so it is very uncertain whether they suffer from PFS.

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