Hello,
my free test,total test and DHT are all above normal.However I am suffering,like all of us,and my recent Adiol-G reading was at 3.40(rock bottom).I’m having a tough time understanding some key points despite all my searching about this site.Could someone please answer these questions:
#1)If Adiol-G is the indicator of 5ARII activity,then why is my DHT level high? 4.59nmol/L Range is 0.86-3.40 nmol/L.
#2)I realize that some DHT(30%) is made by 5ARI.Where in the body is 5ARI found?I ask this because I’m still losing hair(at a slow rate) for the last 2 years since quitting Fin.
Thanks for any help as I’m still new to all these concepts.
You are correct that DHT can be made from 5AR1, so the argument that has been put forth by many is that the body is making the DHT via 5AR1, hence elevated DHT, yet low Adiol G, as this can only be made from the type 2 isozyme.
According to someone (Alex Miller) who posted on another forum and is a neurology/biology student: “5AR1 is present mainly in the brain, muscle, liver and in sebaceous glands. 5AR2 is referred to as the “peripheral 5AR” since it is present mainly in the prostate, seminal vesicles, liver and hair follicles. Finasteride is a specific type 2 inhibitor and doesn’t inhibit 5AR1 in significant amounts. But here comes something that not many people know: 5AR type 2 is also expressed in very significant amounts in spinal chord motor neurons, actually in similar amounts found in the prostate.”
I am also attaching a pdf that shows tissue distribution of the two 5AR’s, although it does not encompass all types of tissue.
Tissue Distribution and Ontogeny of Steroid 5a-Reductase Isozyme Expression.pdf (2.07 MB)
Thanks alot for helping to clear this up.Well this makes total sense because I forgot to mention that I have very oily skin(mainly my forehead and nose).And I do not have brain fog.So I guess I’m producing DHT in those areas at a high rate(hence the high DHT reading)
gcac, that’s a very informative post, I strongly believe correcting 3-adiol g levels is a piece to the puzzle that is missing.