PSSD from Fluoxetine

Welcome to our community. Please fill in the following template as a way of introducing yourself, and helping others to understand your background and situation.

Where are you from (country)? USA

How did you find this forum (Google search – if so, what search terms? Via link from a forum or website – if so, what page? Other?) PSSD Forum

What is your current age, height, weight? 27, 183cm, 85kg

What specific drug did you use (finasteride, dutasteride, saw palmetto, isotretinoin/Accutane, fluoxetine, sertraline, citalopram, leuprorelin, etc…)? Fluoxetine

What dose did you take (eg. 1 mg/day, 1 mg every other day etc.)? 20mg/day

What condition was being treated with the drug? Panic disorder

For how long did you take the drug (weeks/months/years)? ~10 years

How old were you, and WHEN (date) did you start the drug?16 years old, 2009

How old were you when you quit, and WHEN (date) did you quit? 27, March 2019

How did you quit (cold turkey or taper off)? Taper

How long into your usage did you notice the onset of side effects? I had no side effects for around 9 years

What side effects did you experience that have yet to resolve since discontinuation? Erectile dysfunction, low libido, emotional blunting, penis curvature, genital numbness

Check the boxes that apply. You can save your post first, then interactively check/uncheck the boxes by clicking on them. If your symptoms change, please update your list.

[x ] Loss of Libido / Sex Drive
[ x] Erectile Dysfunction
Complete Impotence
[ x] Loss of Morning Erections
[ x] Loss of Spontaneous Erections
Loss of Nocturnal Erections
Watery Ejaculate
Reduced Ejaculate
[ x] Inability or Difficulty to Ejaculate / Orgasm
Reduced Sperm Count / Motility

[x ] Emotional Blunting / Emotionally Flat
Difficulty Focusing / Concentrating
Memory Loss / Forgetfulness
Stumbling over Words / Losing Train of Thought
Slurring of Speech
[ x] Lack of Motivation / Feeling Passive / Complacency
Extreme Anxiety / Panic Attacks
Severe Depression / Melancholy
Suicidal Thoughts

Penile Tissue Changes (narrowing, shrinkage, wrinkled)
[x ] Penis curvature / rotation on axis
Testicular Pain
Testicular Shrinkage / Loss of Fullness
[ x] Genital numbness / sensitivity decrease
Weight Gain
Gynecomastia (male breasts)
Muscle Wastage
Muscle Weakness
Joint Pain
Dry / Dark Circles under eyes

Prostate pain
Persistent Fatigue / Exhaustion
Stomach Pains / Digestion Problems
Constipation / “Poo Pellets”
Vision - Acuity Decrease / Blurriness
Tinnitus (ringing or high pitched sound in ears)
Hearing loss
Increased hair loss
Frequent urination
[ x] Lowered body temperature

Other (please explain)

What (if any) treatments have you undertaken to recover from your side effects since discontinuation of the drug? Current regimen: shilajit 250mg,butea, fish oil, multi vitaminn, coq10, b12, chromium, pregnenolone, proviron, LDN naltrexone, TRT, HCG.

If you have pre or post-drug blood tests, what hormonal changes have you encountered since discontinuing the drug (please post your test results in the “Blood Tests” section and link to them in your post)? On TRT so not applicable

Anything not listed in the above questions you’d like to share about your experience?

Tell us your story, in your own words, about your usage and side effects experienced while on/off the drug.
Some more info from ~11 months ago -

1- What is your gender?
2- Why did you take antidepressants in the first place? and for how long were you on them? which med?
I have anxiety/panic disorder. I have been on Fluoxetine for ~9 years. I started at the age of 17 and am now 26 years old.
3- How was your sexual and emotional function before antidepressant intake?
It is difficult to remember exactly. I would say I may have bordered on depression like symptoms but this is strongly tied to stress induced from outside factors. I could be happy or sad. In fact the last time I’ve cried was a year or so before starting SSRIs. Sexual function was always good but again I was a teenager going through puberty. I do remember having a very short refractory period, morning wood, random erections, etc.
4- What are your symptoms exactly and when did they start? sexual dysfunction alone, or cognitive/emotional/hedonistic as well? which symptom is bothering you the most?
Erectile dysfunction
Low libido
Some anhedonia
Some numbness to happiness/sadness, very little empathy
Brain fog
Difficult to feel “love”
Reduced genital sensation. Also loss of sensation in areas of my big toes but this may be unrelated.

Erectile dysfunction and low libido bother me the most.

5- What meds/suppplements have you tried so far?
Creatine, L-Citrulline, Proviron, Sildenafil, Cialis, Gingko Biloba, Choline Bitartrate, Pregnenolone, DHEA, Clomiphene, Arimidex, Anastrozole, Niacin, Vitamin C, Tribulus Terrestris, Boron, Fish oil, Selenium, Kelp (Iodine), Glutamine, L-Carnitine, Phosphatidylserine, ZMA (Zinc, Magnesium, B6), Korean Ginseng, Theanine, Fenugreek, Mucuna, Taurine, Wellbutrin

This is what worked:
Sildenafil/Cialis - Works for getting an erection in most cases. A slight libido boost as well at times. I think this stems from the thought that my penis will actually work.
Proviron - This was the only other thing that worked. I had a great window of 5 days where I felt great libido wise. I felt much more assertive, confident and all around better. Spontaneous erections, strong desire, no ED during sex. These effects occured on 50mg/day. At the end of 5 days I noticed the effects decreasing. I tried 75mg and then 100mg without any improvements. My “baseline” while being on Proviron is better than not being on it but the small boost isn’t worth continued use I believe.

6- Do you have access to meds without prescription (buy online), or would strictly require a prescription for meds to try?
I live in a country where I can get most prescription meds OTC. If I cant find it here I can buy them online.
7- Can you tolerate galicky foods? what about proteins?
No issues with food
8- Have you done any blood testing? what were the results?
I began working with a doctor 3 years ago to help my low testosterone levels. I was on Clomiphene, DHEA, Pregnenolone and Arimidex. Other than slightly high cholesterol levels I have no other issues. After Clomiphene, my free T and total T levels were at the top of the range. I don’t believe in using aromatase inhibitors anymore and have stopped AIs 3-4 months ago. There was windows of good sexual function after stopping AIs but it didn’t last while on SSRIs. I’ll be doing another round of blood tests soon.


Hi mkkkbkk,

Welcome to our forum! I am sorry that you are going though this, but you have come to the right place.

You may have heard that the staff of this forum strongly suspects that various drugs, including many anti-depressants, finasteride (Propecia, Proscar, generics) and Isotretinoin (Accutane), cause what appears to be an identical condition as a result of endocrine disruption through androgen deprivation.

In this context, your brief improvement on Proviron, a powerful androgen, is interesting, as is the curvature of the penis, which quite clearly points at local physical changes beyond the “mental” effects often attributed to PSSD.

To collect systematic data about the symptomatology of the various patient communities, we have created a survey based on scientifically validated questionnaires. The survey has already yielded interesting results and has supported our efforts to get scientists interested in this condition. Currently, 90 PSSD patients have taken the survey and we would like to push the participation above 100. So, it would be highly appreciated if you could help us to do that. You should have received an invite by now. Alternatively, you can click on the bar chart icon on the upper right of this page (on a desktop computer). Please let us know, if you encounter any problems.

Thank you and good luck!