Purely speculation here, but reflecting on @silentpain89’s experience with sage217, i have a feeling that it will be hit or miss just like everything else.
so far psychedellic mushrooms have been mostly positive (correct if wrong) to neutral.
in terms of coping with neuro sides, so far ketamin has helped some people and has been positive to neutral.
nsi189 has also produced really good results for those who have tried
anyone else think psilocybin will probably yield far better results than a direct allo increaing drug which might mess around with the AR