Prolonged use of finasteride induced gonadal sex steroids alterations, DNA damage and menstrual bleeding in women

Abstract

The aim of the present study was to examine the effect of prolonged use of finasteride on serum levels of dihydrotestosterone (DHT), estradiol (E2), progesterone, testosterone and androstenedione in women during the menstrual period. Further, to screen and compare the 5α-reductase activities through the expression of SRD5A1, SRD5A2 and AR gene and to determine the level of VEGF, VKOR and SAA gene expression and DNA damage. A total of 30 Saudi women aged between 25 to 35 years were enrolled in the study. The selected women were divided into two groups. The first group (n=15) received 5 mg finasteride/day for prolonged period of one year and second group (n=15) was taken as a healthy control. ELISA technique was used for measuring the serum levels of the targeted hormones and Comet assay was used for checking the DNA integrity.Our findings revealed significant decrement of DHT, E2, p sterone and androstenedione levels and elevated levels of testosterone in group treated with daily oral doses of 5 mg finasteride/day compared to the control subjects. mRNA expression suggested that finasteride has concrete effects on the gene expression of the selected genes from the treated group in comparison to the control group. In addition, finasteride induced DNA damage and heavy menstrual bleeding was noted in women treated with finasteride. In conclusion, the present findings revealed that finasteride has adverse health effects in women associated with gonadal sex steroids alterations, DNA damage and heavy menstrual bleeding with no consensus in treatment of androgenetic alopecia in women.

https://www.ncbi.nlm.nih.gov/pubmed/31967291

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It would be interesting to read the full paper. If someone can find it and post some of it?

mRNA expression suggested that finasteride has concrete effects on the gene expression of the selected genes from the treated group in comparison to the control group.

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Yes, that’s a key finding but we need the full paper to understand exactly what this means.

The conclusion of the study is that Finasteride should not be given to women for alopecia. I would imagine if this study was done with men, it would show similar DNA damage. So what do we do with this info? they appear to have identified which isoenzymes get changed. Isn’t this the smoking gun we have been looking for? Notice the researchers in this study have no conflicts of interest with big pharma.

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My bad. Posted this right after you did so the topic was merged.

Not sure why this is getting pushed down. Seems to be pretty significant, especially with the portion about changes In genome expression. Has this been proven by any other studies?

Also, It’s clearly possible to test for genetic damage, what is the major roadblock for any of us getting the same test? Being able to prove genetic damage would seem to me to be a very significant marker in the clinic diagnosis of PFS.

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Seems like this is a solid news item for a blog post.

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