Funny you say the 23andme testing and I read about it somewhere. Is there somewhere on the site where I can post my results for 23andme and people can help analyze it?
We are on the same page as far as extensive testing. I have had two rounds of testing and I am going to wait 2 6 more weeks for my third round (2 months apart each) to see if I see any trends. I will post my test results below. I am doing all you have and I might add in these suggestions you had. Why did you add these and what value did you get from them?
Organic acid urine test
Hair mineral test
Urine heavy metal testing
Here is my synopsis and test results.
Background – I am currently a 46 year old, otherwise lean, healthy male who is reasonably fit. 5’6” and 140 pounds as I try to stay in shape. No drug use, no smoking, no alcohol consumption. I took 1.25 mg Finasteride roughly for 6 to 12 months in 2009 with no side effects. Started again Sept 30, 2015. Oct. 10, 2015 was in ER for epididymis with a raging hard-on for about 2 hours. I had two additional bouts of epididymis for the next two weeks which I got through with painkillers just staying at home as I was told by the ER I would adjust to the medication and not worry about it. I started to notice a loss in libido, morning erections and such right after the epididymis bouts(mid October 2015). But I chalked it up to anxiety from separation from my wife (we separated in July 2015) and that sex was not number one on my mind as just repairing our relationship was. However, in hindsight, I doubt a separation that happened 4 months earlier would cause this, but during the time this started I was distracted and sex was not a big thing right then. I even recall talking to my buddy on the phone and not putting two and two together saying…”man, I am surprised, I have not masturbated it in over two weeks.” Prior to October 2015, my libido was super high. I have for the past 20 years masturbated anywhere from 1 to 3 times a day in addition to sex with my wife roughly 4 times a week. I have always had morning wood and spontaneous erections that are at times embarrassing.
From sporadic intimate encounters with my wife from November 2015 to March of 2016 I displayed an erection not to full capacity and I had to really think about it to maintain the erection. Ejaculation was not pleasurable as before. Again, I chalked it up to what we were going through as we were still separated. I started to really worry around April 2016 when we were fully back together. My symptoms did not change from April 2016 to June 2016. I then researched and found out that Finasteride causes these sort of side effects and discontinued June 8th, 2016 without tapering off from the 1.25 mg dose.
My urologist said things would get better within 30 days of discontinuing Finasteride. There was no improvement. I was given a 30 day trial of 5 mg Cialis. That seemed to help maintain the erection somewhat better where I did not have to concentrate on keeping it as much, but it did not help with morning wood or spontaneous erections. Also, I was not able to keep the super hard-on that I am accustomed to where I can control and kind of pulsate the blood in my penis’ head to make the head get bigger and hold it like that. It is just something I knew I could always do and can’t really do now. My urologist ordered basic hormone labs and they were run on 7/28/2015 at 1:44 in the afternoon. So you would think some of the hormone levels like Testosterone would be lower than if this was done in the morning. But you will see I am above the 100 percentile for my age.
My first tests from July 27, 2016
Testosterone – 967 ng/dL range 250-1100
Free Testosterone – 72.5 pg/mL range 35-155
FSH – 5.9 mIU/mL range 1.6-8.0
LH – 5.7 mIU/mL range 1.5-93
Estradiol – 31 pg/mL range <OR=39
Prolactin – 5.5 ng/mL range 2-18
The only major problem with the results below, I did not realize I was 3 days into a Shingles outbreak when they drew the blood and urine for these tests…the shingles I am told was probably from all the stress worrying about PFS as stress and high cortisol triggers it I am told.
My second test results from October 5, 2016
Testosterone – 682 ng/dL range 250-1100 – this went down but for my age still seems fine
Free Testosterone – 42.2 pg/mL range 46-224 - this seems to went down just below the bottom range
Testosterone Bioavailable – 92.4 ng/dL range 110-575 this is below the bottom range
SHBG – 80 nmol/L range 10 to 50 this is super high
Albumin,Serum – 4.8g/dL range 3.6-5.1 this seems ok
FSH – 3.9 mIU/mL range 1.6-8.0 This went down 2 full points, no idea why.
LH – 2.2mIU/mL range 1.5-93 This went down 3.5 points, no idea why. Does it normally fluctuate this much?
Estradiol(Ultrasensative) – 23 pg/mL range <OR=29 this seems ok?
Estrogen, Total Serum – 183.6pg/mL range 60-190 This seems to be high at the top end.
Estrone(E1) – 39 pg/mL range <OR=68 This seems to be ok.
Prolactin – 5.6 ng/mL range 2-18 This stayed about the same on the low side which is good.
DHT – 60ng/dL range 16-79 This seems to be really good, especially given my low Free & Bio Testosterone or am I reading it wrong? It does not seem to make sense. Although I did take 20 grams of Creatine for 5 days loading. But when I found out I was getting my tests, I stopped it for 6 days to take my test. I read it should be out of my body probably in a few days as I read Creatine can help your DHT levels.
Progesterone, LC/MS/MS - <.1 ng/mL range <OR=.2 So this seems to be good as it is low which allows me to convert Testosterone to DHT, correct?
Progesterone (another one with different range) - <.5 ng/mL range <1.4
Pregnenolone - <5ng/dL range 13 – 208 Wow, I am super low. I thought this was the top level hormone that converted to progesterone, DHEA, testosterone, estrogens, etc. So how if I am so low, can I have decent Testosterone levels?
DHEA S – 172 mcg/dL range 106-464 I am thinking this is a little low, probably due to my low Pregnenolone?
3A Androstanediol Glucuronide – 764 ng/dL range 251 – 1500 This seems in the middle? Good, bad?
TSH – 1.4 miU/L range .4 - 4.5 This seems to be pretty close to perfect.
T4 Free – 1.1 nm/dL range .8 – 1.8 This seems to be low.
T3 Free – 2.5 pg/mL range 2.3 – 4.2 This seems to be low.
T3 Reverse – 36ng/dL range 8 – 25 This seems to be super high. I don’t know what that means.
Could these thyroid levels be off due to the Shingles outbreak I was having when they drew the blood?
PSA Total - .5 ng/mL range <OR=4 This seems to be good.
PSA Free - .1 ng/mL There was no range for this test.
PSA % Free – 20 >25% calc This was flagged as low. I have no idea what it means. Does anyone else?
IGF-1 – 141 pg/mL range 52-328 This seems normal I think.
IGF Binding Protein 3 – 3.8 mg/L range 3.3 -6.7 Not sure what this reading means on the low side.
Cortison Serum – 1.6 mcg/dL range 1.2 – 3.5 This seems ok, weird my 24 hour level is so sky high. Ideas?
Corticosterone – 251 ng/dL range 59 – 1293 This is on the low side, not sure if that is good or bad. Thoughts?
Deoxycorticodterone - <16 ng/dl range <OR=15 I have no idea what this is. Any explanations?
Androstenedione – 63 ng/dL range 40 – 190 This seems pretty low. No idea why.
Deoxycorticodterone - <16 ng/dl range <OR=15 I have no idea what this is. Adreanal glands? Possibly from the Shingles outbreak? Any thoughts on the results?
17 Hydroxypregenolone – 18 ng/mL range <OR=905 Is low good?
17 Hydroxyprogresterone – 45 ng/dL range 33-295 Is low good?
Aldosterone – 10 ng/dL range 3 – 16 This seems average I guess.
Creatinine 24 HR – 2.3 range .63 – 2.59 Could this be skewed due to Creatine I spoke about before?
17 Ketosteroids 24 HR – 7 mg/24hr range 8 – 20 This is low meaning adrenal fatigue or tumor?
ACTH Plasma – 11 pg/mL range 6-50 This seems to be on the low side which is adrenal issues/tumor?
Hepatic Function Panel
AST – 92 U/L range 10 – 40 High, probably due to shingles outbreak
ALT – 75 U/L range 9 – 46 High, probably due to shingles outbreak
Bilirubin, Total – 1.3 range .2 - 1.2
Magnesium – 2.2 mg/dL range 1.5 – 2.5 This seems good.
Zinc – 74 mcg/dL range 60 – 130 A little low, no biggie.
Vitamin D1 – 78 pg/mL 18 – 72 A little high
My one concern is my T, Free T, FSH, LH all went down from my first test 2 months after I stopped finasteride to the test that was 4 months after I stopped. So I don’t know if I am getting worse or if it is just a normal fluctuation of the day. As in reality, all those levels except for the Free T are probably better than most people here. I guess the real thing is my symptoms have not change with those hormone value changes so it is sort of a moot point. I am just hoping it is not starting to go downhill. But I will keep positive and hope not
Here is even a chart I created of the hormone levels and how they synthesis.