Hey Prop,
Yes i know it sounds ominous… “Irreversible” in lamens terms, means a longer term of MOA-B inhibition. That is, MOA-B levels will recover far quicker in a reversible inhibitor than if you used an irreversible inhibitor. If your using low dose selegiline ie: 2.5 grams or under, MOA-B levels will return to baseline a few weeks after your last dose.
Harmaline is a selective MOA-A inhibitor- which acts on dopamine, adreneline, melotonin and serotonin. MOA-B is more so responisble for the breakdown of Phenethylamine and Dopamine. Dopamine is the intended target here, as MOA-A inhibition is far more complicated given its range of effects. Hence the rational to use selegiline; Dopamine’s ability to regulate motivation, pleasure and libido are well documented, selectively inhibiting its breakdown would potentially augment our capacity to experience those things. (Which arguably are the most crushing and persistent side effects of PFS).
Furthermore, selegiline the only MOA-B inhibitor that a) has no dietry precautions and b) has been EXTENSIVELY tested in medical literature for 3 decades and has been shown in quite a few studies to have multiple beneficial, neuro-protective effects.
Heres pretty much every abstract on it for reference.
lef.org/prod_hp/abstracts/deprenylabs2.html