Thanks for the updates @Xorack.
I tried mifepristone on 3 different occasions, very low dose but no effect.
mifepristone is the opposite of progesterone, no ?
@Crossroads : I tried oral progesterone, it had some effects, but I was not really sure. I think I swallow instead of keeping it in the mouth, that’s why in the butt is better for absorption.
Still having strong erections … that’s really weird. No sex drive and no pleasure when I try to j…k o.f … so it’s not meant to be a cure. But it has a strange effect. Maybe it can help some guys here ? I regret I didn’t try earlier (in the butt I mean … the pills in the butt, no something else).
I will keep going for 10-15 days and then stop gradually. And try again in a few months, maybe.
What are the ingredients of the progesterone you are putting up your butt?
In french
“ Principes actifs: Progestérone
Excipients à effets notoires [ ? ] : Huile d’arachide
Autres excipients: Lécithine de soja, Enveloppe de la capsule : Glycérol, Titane dioxyde, Fer oxyde rouge, Gélatine”
je comprend.
And this form of progesterone with peanut oil is to be placed in the anus? Where did you get this from?
Yeah… you take the pill and put it in your anus. Not pleasant, except if it’s your thing. I tried to take it sublingual but too many times I swallowed the pills, so it was not really effective.
I bought it online… I will try to make my doc prescribe it to me.
I don’t think it’s a cure. Maybe there is an explanation for why progesterone gives me strong erections (today even a bit of libido, but it doesn’t mean anything). I won’t encourage you to try, but if you have already nothing to lose and want to try anything, even things that can make you worse. Be careful. I do desperate things because I want to die and I have to try everything before shooting myself. If you’re not in that situation don’t try.
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Who else tried or trying?
Didn’t really help me. Just gave erections.
I stopped but maybe it’s because I need higher progesterone level like Dr Will Power suggested…
Thank you.
My baseline is how you describe yourself after the progesterone, I can get strong erections but have no libido or feeling down there
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Im having some pelvic floor pain reaching upto the base of my penis.
I’m wondering if rectal Progesterone can help me?
I still have mental libido, and if I wait a few days between ejaculations, I can still get erections from porn & interaction with women.
But I feel like my pelvic muscles (paired with maybe autoimmune & hormonal issues?) is holding my sexual life back.
You’re supposed to take it … in the butt. At least that’s what Dr Will Power recommend. Sometimes I do that, most of the time I take it sublingually.
I don’t know if it can help you, maybe it can make you worse. I cannot say.
I test a lot of things because I have nothing to lose anymore.
Maybe you should be cautious and wait for a real cure.
Have you had any communication with Dr. Powers?
Did you take this with the recommendation & supervision of a dcotor? or did you just take it on your own because you saw it recommended online by Dr. Powers?
Because he was recommending it for PFS patients. He pretend it can cure PFS. I don’t believe in that but I had to try anyway.
My take on Progesterone is that it antagonizes Estrogen, specifically E2. The two share an inverse relationship. Lower E2 in turn results in higher DHT. High DHT/E2 ratio is usually marked by enormous erections but low(ish) libido whereas low DHT/E2 provides high libido but weak(ish) erections. There may be other factors at play, however.
I wonder if rectally administered progesterone paired with proviron would work? Somthing I might try in the future still waiting on my proviron to come in first.
I think we need to have a more clear understanding of the mechanisms behind rectally administering Progesterone.
I was listening to a lecture & reading some things by Will Powers. It sounds like he goes the rectal route due to the efficacty of absorption. But he’s giving it to MtF trans to help their transitions (to aid in breast development & modulating hormone levels in the body without using T blockers).
He also says he administers a bio-available version of progesterone, if I recall correctly, which he says doesn’t pose the negative side-effects & cancer risks of the pharmaceutical version. However, I only caught this in passing in a lecture.
Doomed’s theory is interesting. I have seen Progesterone used in women to balance Estrogen levels. The problem is I wish we could correlate our attempts with some lab work.
Xorack, have you checked your T, DHT, Estrogen, E2 levels before & after trying Progesterone? How about you doomed80?
No
I stopped Progesterone yesterday and I don’t think I’m going to try anytime soon. It’s not the cure … we need something that can edit our genes the way they were before taking Finasteride/Dutasteride/Lupron/… and we will wait a very long time.
I’d surmise that would be a double down. Depends on your basal hormonal profile.
Never touched P4 before so can’t tell. However, I’ve had LH, FSH, T, E2, Cortisol, DHEA-s, TSH, ft4, ft3, Prolactin, SHBG all measured numerous times with E2 and DHEA being my outliers (borderline low). Cortisol being high(ish) indicates that most of Preg is going P4 pathway (see flowchart below). This leads me to believe exogenous P4 isn’t ideal in my case. I’m on oral DHEA with decent results.
@inbrugge
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Who tried beside me ?
DrWillPowers said he cured some PFS patients with that. I don’t believe him at all but maybe I’m paranoid. You need to have normal testosterone level and to take in the butt Progesterone (200mg I suppose) and Pregnenolone orally.
I will soon try again, because I’m desperate and cannot tolerate the pain, I need to do something… but with Pregnenolone and 600mg everyday, for 6 months.
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He’s full of crap in my opinion if he was so confident in being able to cure this he would have contacted the PFS foundation by now. Did your baseline get worse after using progesterone?
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