pregnenolone

[Jonson]

so i ear more and more evidence about it connected to pfs, and it has a lot of benefits.
what do you think about that?

[Haglaabla]

When I take a dose of oral pregnenolone, it produces a feeling of “fullness” that has been lost since i started fin. But if 5ar-enzyme remains unfunctional, pregnenolone does not metabolite correctly and causes symptoms propably linked to increase in estrogen (ED symptoms, feeling of pressure in penile root). Pregnenolone is also a GABA-A antagonist, which means it has a kind of “anti-sedative” psychological effect. Normally, if 5ar-enzyme is working properly, pregnenolone is metabolized to many other neurosteroids, including GABA-A agonistic allopregnenolone, whichs sedative effect subverts the anti-sedative effect of pregnenolone.

However, i’ve noticed that a 5ar-booster, Phospatidyl Serine dosed some 200-300 mg a day, does something good in my body. When i take phospatidyl serine alone, it feels like it’s restoring normal functions. If I take it after a testosterone booster, i feel definite DHT-effects. If I take it with pregnenolone, it provides A LOT better outcome than pregnenolone alone.
I think the shut-down of 5ar-functions many of us experience are also responsible of the decrease of pregnenolone, because phospatidyl serine alone seems to produce many of the same psychological effects that pregnenolone does. It’s like our bodies are trapped in a stress-reaction cycle known as “pregnenolone steal”

I don’t know how many of us have similar symptoms with me, but to me the “intoxicating” effect of finasteride seems quite similar with stress reaction: http://en.wikipedia.org/wiki/Stress_%28physiology%29#Central_nervous_system_.28CNS.29

Also the fact that a licorice root extract, which increases cortisol, makes me feel like shit, suggests that my cortisol levels are already high (cortisol elevate in stress-reaction).

Whenever i’ve took 200-300 mg of phospatidyl serine a day, i’ve experienced significant improvement within a couple of days. When i run out, i crash hard.

My life has been a mess so i’ve never tested this properly nor have any lab-results of my hormone profile (although i’m finally scheduled to a doctors appointment and am going to get some tests done). Low dose of pregnenolone cream daily with 300 mg of Phospatidyl Serine daily is surely my next attempt to recover. I’m starting this as soon as my orders arrive and will let you people know if it’s working.
Hopefully pregnenolone cream is more bioavailable than tablet form, because tablets only seem to work when taken rarely.

Anyways, pregnenolone does work at least for me, and definitely does remind me of something that i once was a long time ago. I also highly recommend phospatidyl serine to anyone experiencing fatigue and ED-problems.

[Haglaabla]

Just to update: The brand of phospatidyl serine i have used, has obviously changed their manufacturing procedure since the liquid gelcaps are more yellowish than before. The good ones were darkish brown. These new yellow pills don’t work for me. Got to send some customer feedback to manufacturer.

Also: Pregnenolone cream doesn’t seem to absorb any better than pills. I do not notice any effect using it, even at a dose of 60mg.

So no help for me so far… blah.

Has anyone else noticed better absorption using skin-creamed pregnenolone than oral pills?

[Cap]

I took pregnenolone pills for a bit but then I realized according to my bloodwork I already have preg coming out of my ears so I thought it was redundant and stopped. Didn’t notice any changes while taking it though.

[Costa]

It definitely has a calming effect at 25mgs per day. Do not experiment with larger doses as it converts to other hormones (allo, dhea) and causes further imbalance.
I would like to see the results of 25mgs a day for 1-2 months with only preg. Maybe someone who tried this could inform us.

[Raberduck]

@Costa

It definitely has a calming effect at 25mgs per day. Do not experiment with larger doses as it converts to other hormones (allo, dhea) and causes further imbalance.
I would like to see the results of 25mgs a day for 1-2 months with only preg. Maybe someone who tried this could inform us.

Calming effect? For me it’s the complete opposite, I get very energetic and can’t sleep while on it.

@Haglaabla

Pregnenolone is also a GABA-A antagonist, which means it has a kind of “anti-sedative” psychological effect

Thats’s most likely the reason why.

[Mark2012]

Has anyone else here tried Pregnenolone cream ?

[Mark2012]

Interesting article I found on pregnenolone.

Pregnenolone—The Basics
articles.mercola.com/sites/artic … enals.aspx

Pregnenolone, like DHEA, is a steroidal hormone manufactured in the body. Pregnenolone is a precursor hormone synthesized from cholesterol, principally in the adrenal glands, but also in the liver, skin, brain, testicles, ovaries, and retina of the eyes.

Steroids are a large family of structurally similar biochemicals that have sex-determining, anti-inflammatory, and growth-regulatory roles. Indeed, pregnenolone is the grand precursor from which almost all of the other steroid hormones are made; including DHEA, progesterone, testosterone, the estrogens, and cortisol. Despite its powerful metabolites, pregnenolone is acknowledged to be without significant side effects, with minimal or no anabolic, estrogenic or androgenic activity.

Pregnenolone has been found to be 100 times more effective for memory enhancement than other steroids or steroid-precursors in laboratory mice. Pregnenolone appears to be the most potent memory enhancer yet reported in animals. Pregnenolone has been reported to not only make people smarter but happier and enhance ones ability to perform on the job while heightening feelings of well-being. Pregnenolone has also been reported to reduce high stress induced fatigue.

As is the case with the steroid-hormone precursor DHEA, pregnenolone levels decline with age. Many physicians and scientists believe that replacement of pregnenolone to youthful levels is an important step in the treatment of aging and symptoms of aging. Pregnenolone may be one of the most important hormones because it seems to have a balancing effect. It is a precursor to many other hormones and may be able to bring the levels of other hormones up or down as needed.

Other benefits of pregnenolone may include stress reduction and increased resistance to effects of stress, improvement of mood and energy, reduced symptoms of PMS and menopause, improved immunity, and repair of myelin sheaths.

Pregnenolone also operates as a powerful neurosteroid in the brain, modulating the transmission of messages from neuron to neuron and strongly influencing learning and memory processes. As with DHEA, pregnenolone levels naturally peak during youth and begin a long, slow decline with age.

By the age of 75 our bodies produce 60% less pregnenolone than the levels produced in our mid-thirties. For this reason pregnenolone is one of the biomarkers of aging. Like counting the rings of a tree, by measuring the level of pregnenolone at any given point of a person's life, it is often possible to make an educated guess as to his or her age.

Some other hormones that decline with age are DHEA, the estrogens, testosterone, progesterone and growth hormone. These are considered biomarkers of aging as well. Since pregnenolone provides the initial raw material from which all the other steroid hormones are made, some of our other hormones will decline in a parallel fashion.

While our youth-giving hormones are diminishing, loss of quality-of-life progressively settles in. We slowly begin to experience physical and mental decline; loss of energy, memory loss, visual and hearing impairment, arthritis, cardiovascular disease, and sexual decline, just to name a few. Supplementing small amounts of these neuro-hormones may slow these age-related processes, improving one's quality of life by rejuvenating the body to more youthful functioning.

Pregnenolone—A Little History

Research on pregnenolone, as well as usage of pregnenolone, dates back as far as the 1930's. Human studies were conducted in the 1940's on factory workers to test the effect of pregnenolone on anti-fatigability and autoimmune disorders, including rheumatoid arthritis. The results were successful and improvements were noted. Even though pregnenolone was proving to be not only effective, but safe as well, it was discarded when Merck's newly introduced pharmaceutical agent, cortisone, was announced to be a cure-all for rheumatoid arthritis in 1949.

Soon after cortisone and cortisol came into use, the synthetic steroid hormones dexamethasone, and later prednisone, were introduced. Remember that these steroids are hundreds of times more powerful than pregnenolone (or DHEA for that matter). Because they could be patented, it was more politically and economically advantageous for pharmaceutical companies to promote these drugs rather than pregnenolone. Additionally, these steroids were very fast acting compared to pregnenolone. Users and doctors preferred the quick fix. However, these steroidal compounds proved to have serious downsides, including compromising the immune system and inducing osteoporosis, among other serious complications.

Even though cortisone and cortisol are stress hormones that are natural to the body, they have historically been and continue to be administered in pharmacological doses rather than at physiological amounts natural to the body. The pharmacological levels at which cortisone and cortisol are generally administered give them a risk profile not unlike that of the synthetic hormones.

Scientists have been studying the impact of hormones on learning and memory for many years. Various studies have found that pregnenolone enhances motivation, the ability to acquire knowledge, and long-term memory. A research group of industrial psychologists conducted studies in the 1940's to test pregnenolone on students and workers for the ability to enhance job performance. They found that the students/workers had a markedly improved ability to learn and remember difficult tasks.

It is also amazing that pregnenolone not only enhanced job performance of the students/workers; but they additionally experienced heightened feelings of well-being. The same research group performed a study on factory workers to see if pregnenolone could improve their work productivity. Productivity increased most notably in the workers whose situations were considered the most stressful; for example, the workers who got paid per piece and whose living depended on their productivity. Improvement was noted, but less so, in workers who got paid a fixed wage regardless of their productivity levels. Not only did pregnenolone improve productivity for both groups, but the workers also reported enhanced mood.

As previously mentioned, despite successful results, research on pregnenolone halted in the 1950's when cortisone became available as an immediate cure-all. Because pregnenolone, unlike cortisone, couldn't be patented, pharmaceutical companies had no financial incentive to pursue the research. It is unfortunate that pharmaceutical companies are governed by a financial system and healthcare system that imposes the requirement that for a molecule to be profitable it must be patentable. If there were half as many studies done on pregnenolone as the patented drugs, pregnenolone's therapeutic potential would be expected to be far reaching.

[Lostinaustin]

I’m getting pretty decent results on 10 mg a day preg currently. Been taking it a week and I’ve noticed an increase in fatigue and brain fog symptoms. Sexual symptoms remain the same though.

[Tomas]

Increase on fatigue???

[Lostinaustin]

Sorry that was worded weirdly, I meant an increase or improvement on those symptoms. Whose to say if it will keep up, plenty of people say stuff stops working after a few weeks but I’m feeling a lot better than my baseline currently

[Lostinaustin]

Just want to update that I’m still doing 10mg preg a day and my brain fog and fatigue symtoms are greatly improved while on it. I skipped a day last weekend and woke up feeling like shit so it is doing something for me.

[ll_amp_Prosper]

What brand are you taking? Thanks

[Lostinaustin]

Hey there, it’s Pure Encapsulations -… https://www.amazon.com/dp/B001680V0E?ref=ppx_pop_mob_ap_share

I wanted to start my own topic on this actually. I’ve been taking this stuff once a day for 2 weeks or so now and it is doing wonders for my fatigue symptoms. I forgot what it was like to feel this refreshed and energized. It isn’t doing anything for my sexual symptoms and my brain fog is still debilitating on certain days but I can actually make it through the day without coffee or feeling like I need to nap. Today I added 5mg dhea from the same manufacturer but haven’t noticed any additional benefits.

[anon73159565]

Any news on this?

[Mercked]

Does it help you stay asleep through the night?

[Lostinaustin]

I haven’t really used pregnenolone since posting that. I had a period of a few weeks where my fatigue was really manageable and now it’s back to crap for the most part. I wouldn’t take preg to stay asleep though it made me incredibly wired and sweaty for hours after taking it. Only thing I’m using currently is l theanine which is helping with anxiety somewhat