Copious Pre-Ejaculation: Small Glands—Major Headaches
andrologyjournal.org/cgi/reprint/28/3/374
"…
Dr Jacob Rajfer posed the following question for
discussion on Androlog:
Dr Dana Ohl, citing evidence suggesting 5-a-reductase
inhibition as a rational therapy, responded:
Investigators report immunohistochemical markers,
prostate-specific antigen (PSA) and prostate-specific
acid phosphatase, in the accessory sex glands similar
to those found in the prostate (Elgamal et al, 1994;
Rui et al, 1986).
The regulation of the glands’
embryologic and postnatal development as well as
their functions thus may be regulated by DHT
(Chughtai et al, 2005; Raeside et al, 1997). A reasonable
clinical hypothesis is that to attempt to gain control
over the glands’ secretions, clinicians may consider using
5-a-reductase inhibitors, cited here by Dr Ohl successfully.
Dr Steven Kaplan reported similar results using a 5-areductase
inhibitor:
“… While infrequently
reported, copious pre-ejaculation causes a great
deal of social and physical distress. Based on the
literature and reports of physicians on Androlog,
clinicians may attempt a course of 5-a-reductase
inhibitors for symptomatic management.”