Post-Selective Serotonin Reuptake Inhibitor Sexual Dysfunctions (PSSD):

Post-Selective Serotonin Reuptake Inhibitor Sexual Dysfunctions (PSSD): Clinical Experience with a Multimodal Approach

Yacov Reisman, Tommaso B. Jannini, Emmanuele A. Jannini

Submitted: 28 December 2021 | Revised: 24 February 2022 | Accepted: 18 March 2022 | Published: 1 August 2022

Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.


Background: Post-SSRI sexual dysfunction (PSSD) is a set of heterogeneous sexual disorders, that may arise during the administration of antidepressant Selective Serotonin Reuptake Inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitor (SNRIs) and may persist after their discontinuation. PSSD is commonly associated with sexual problems with marked distress and poor quality of life. To date, however, no effective treatment is available. The study describes the clinical experience with a newly introduced systems sexology approach involving bio-psycho-social interventions. Methods: In this study we retrospectively analyzed (from July 2019 to July 2020) twelve PSSD male patients (mean age 31.3 ±± 6.21 years old) treated according to a recently introduced approach involving system sexology and bio-psycho-social interventions. The protocol was based on a combination of lifestyle changes, nutritional supplementation, pharmacological and behavioral interventions. Results: 12 patients with high probability of PSSD were selected. Patients reported a significant improvement in all International Index of Erectile Function-15 (IIEF) domains and Orgasmometer scores from the baseline at 6 months of follow-up. Conclusions: This study described for the first time a feasible and handy treatment procedure for PSSD, framework to improve patients complains, sexual function and satisfaction, and quality of life. Future randomized, placebo-controlled clinical studies with bigger cohorts will be needed in order to better assess this efficacy and confirm our results.


thanks for sharing. encouraging to see continued interest in these issues. and to see researchers exploring clinical standards for diagnosis and symptom management.

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Each study like this makes it more and more difficult to dismiss our shared issue

Nobody would prescribe blood pressure drugs without checking your blood pressure first, so why would anyone prescribe serotonin drugs without checking your serotonin levels first?

Edit: STAFF, PLEASE HELP! I keep getting this popup when trying to make a post or reply to a message:

“First day” of what?

“New user” of what?

Is that Earth “seconds” or Mars seconds? LOL!

I also cannot like old posts.

It has been going on 2 days. Am I the only person?

Am I banned or what sort of glitch is this?


Seems there was a setting changed in admin. You should be fine now but let me know if not.


So far so good, thanks!

Now the pencil icon is suddenly nowhere to be seen. Scratch that, the pencil has returned.

However, the translation feature is still absent. I reached out to staff in May about an error that occurred when translating posts that have one-box links. I was informed plugins such as the translation feature entail bugs and the resources to patch them were lacking. With that considered, my theory is the translation feature was discarded to help stabilize things. Did I guess accurately? Since tone does not carry over in text, this is not intended to come across as complaining.

There are many plugins that had to be disabled as they were no longer supported by our forum software and were hence making the platform unstable. Translation was unfortunately one of them.

There are several good translation tools you can install, including DeepL, which has a browser plugin and makes translation very easy.

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