Positive experience with GABA supplementation

Therapeutic Efforts
#41

Keep in mind the possibility of microbial involvement or the processing of glutamate to GABA might be a more sophisticated way the body handles this regulatory process.

serotonin and microbiota connection may be of particular interest given the evidence that the strain of Bifidobacterium infantis 35624 can increase plasma concentrations of serotonin precursortryptophan (20). Apart from serotonin, microbiota can influence the enteric nervous system by producing other locally acting neurotransmitters, such as GABA, melatonin, histamine and acetylcholine and by generating active forms of catecholamines in the gut lumen

GABA‐producing Bifidobacterium dentium modulates visceral sensitivity in the intestine

The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2982.2010.01520.x

GABA-PRODUCING CULTURABLE BACTERIA DERIVED FROM THE HUMAN
GASTROINTESTINAL TRACT

#42

You mean the gaba might have had a positive effect on gut flora? Sorry, as soon as very scientific terms come into things my brain generally stops processing the information.

#43

No, no, no. lol. But yes it could be a two way street.
I mean dietary intake of Glutamate gets converted to GABA from select commensal microbes.
Or the ability of.
Im guessing based on how Zenflore is marketed, it might fall into this category as well.

#44

Ah right, yes I also didn’t take that the past two days, though about to take my dose for today now my breakfast isn’t sitting on my stomach

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#45

Some people get help with acids, some don’t. If I try an acid and feel nothing, I move on and experiment with others. I mix and match all the time. I do better when I take them then I do without them. When you study on them, it actually makes sense. Your genes directly affect your proteins. If your genes are altered, your proteins will be altered too hence an epigenetic change. That’s why I believe amino acids help.

#46

Would you attribute this improvement to GABA or GHB use or both?

#47

Well the last GHB use was months ago, however I got into it in an attempt to open up pathways in my brain according to what I had read about it and what some have written in the past. I found GHB to be extremely beneficial at bringing about sleep and I certainly wouldn’t discount it from being a significant contributor to the improvements I have seen in recent months. I have been wondering if that primed my brain to be more susceptible to the Gaba, though the fact Lostinaustin has reported benefits without previous GHB usage caused me doubts.

Sorry, I realise this is not really an answer, but the truth is I really don’t know.

#48

So after taking a break from Gaba, I took it again last night, after 4 nights off.

In the meantime, I did start taking tryptophan, after finding it in a supps shop and thinking why not. My sleep has been pretty decent, until last night, but I stupidly drank a coke zero (caffeine) in the evening and last night had an awful night’s sleep, also in part because I had an important meeting this morning that I was ill prepared for, so I think I nodded off about three times between 1am and 5am, and then slept through till 8.45, but woke up feeling really odd. I think the lack of proper sleep and the gaba + tryptophan messed me up, nevertheless I actually felt pretty good by the end of the meeting.

However, I did have solid morning wood again this morning, the persistent kind like the first couple of mornings with gaba.

So I am thinking that I am going to maybe interchange the tryptophan and gaba, tonight tryptophan, tomorrow gaba, and see how I go. If that is a crazy idea, I welcome feedback.

#49

Just an update, because of the fact I seem to have improved sleep for a couple of days even after stopping taking gaba, and the morning wood comes back after a break, I am trying out a new system which is:

Night 1: 750mg gaba
Night 2: 2 x 570mg tryptophan (one mid afternoon, one an hour or so before bed)
Night 3: Nothing
Repeat

Last night I had gaba and woke up again with morning wood this morning.

#50

I’m still taking gaba and getting no morning wood. Do feel calmer and more rested however

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#51

Last night was tryptophan night, and I have also started taking L-Arginine (1000mg) before bed along with whichever supp I am taking that night. I woke up again with morning wood, so maybe the Arginine is playing a big part (though I didn’t take that when I first tried gaba and got morning wood).