** Please report your experience with Progesterone **

Therapeutic Efforts Pharmaceutical
#1

How did Progesterone impact your symptoms (while taking)?

  • It persistently improved my symptoms
  • It first improved my symptoms, but then lost effect
  • It first improved my symptoms, but then made me feel worse
  • I felt no real change throughout
  • It made me feel worse without initial improvement

0 voters

Progesterone is a supplement which has often been tried in the past, often with mixed results. Unfortunately the information and evidence regarding this treatment is scattered all over the place throughout the forum. I therefore ask everyone who has tried Progesterone in the past (or still is) to please provide a brief experience report in the following format:

  1. What dosage did you take and for how long?
  2. What kind of formulation did you take and how did you apply it?
  3. How did it affect your symptoms in detail?
  4. Was it self-prescribed or did a doctor prescribe it to you? Did you do any labs?
  5. If you quit, please tell us why?

Please also respond to poll.

As usual with experience threads, please no discussion in this thread as we would like to build a compact overview.

Thanks.

#2

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#3

I tried it for at least two weeks high doses low doses I can not remember exactly but both much higher and lower than the reccomended dose. Did not really cause any changes. Nothing very noticeable.

#4

I would also ask for the people who have tried this, what was your progesterone level before and after usage? This should be asked for any poll regarding any hormonal treatment (whether its Progesterone, Pregnenalone, Total Test & E2 with AI’s or test creams, etc.) Just my 2 cents. I think it’s important to know what levels are before and after you try ANY specific treatment.

#5
  1. What dosage did you take and for how long?

Dose approx. 5mg. Transdermal so I can´t really say. One run in January. Stopped. Started again in February.

  1. What kind of formulation did you take and how did you apply it?

For women. biovea. on the skin. Mostly belly, sometimes legs, forearms.

  1. How did it affect your symptoms in detail?

The effect is hard to describe. I used gabapentin for some months to improve my depression, brain fog and sleep. Progesterone works in the same departmend, but much more effective. When applied you feel nothing special for 5 min, but than you will feel that the sun rises. For me it is a huge difference between taking prog and not taking it.

So mental I have a good feeling. Brain Fog is lifted. More social behaviour. Interests are back.

I had a lot of dental problems after fin. These seem to get better after a while on progesterone.

Sexually I have more nocturnal and morning erections. Still no spontaneus and still difficult to get erections. When I have erections they are fuller and longer lasting. Gland is still not full erected and soft. Penis is not so easy to bend. Semen quality better, but not as good as it should be. One day everything was so good that i thaught I am cured. But now I am not. Not yet.

Side effect is bloating.

  1. If you quit, please tell us why?

I quit one time, because it didn´t cure me right away. And I don´t know if breaks are needed. I gues it is necessary.

#6

Sorry for not responding sooner. I just saw this.

What dosage did you take and for how long?
a small smear (no idea how to quantify that, but it wasn’t much.) I’ve applied off and on since early January. three weeks on, one off, three on, one off, then light-sporadically (1-3x/week since).

What kind of formulation did you take and how did you apply it?
a women’s formula. It isn’t biovea, but no sp and is natural.
rub on palms or occasionally on chest, underarms, thighs, belly etc.

How did it affect your symptoms in detail?
greatly helped with the mental sides.
no real change with libido, sexual performance. Possibly a decrease in performance, hard to say.
no real change in blood work. Possible decrease in T levels while on or immediately off progesterone cream, but need to test more to know for sure.

If you quit, please tell us why?
I tailed off because (a) I wanted to see if the improvements would stay (they did, mostly), (b) because LAE tailed off in his protocol, and © because I never took it on to be a permanent supplement.

Overall, I would recommend progesterone cream. It’s remarkably cheap and I have had positive and persistent gains.

#7

i started the biovea progesterone cream on february 1st 2013,almost straight away my anxiety and depression lifted and i felt my body fill with energy,like it used to feel before pfs,a sort of a nervous energy but in a good way,i felt alive again,going for a run was making me feel on top of the world,even little things like feeling relief when havin a piss and enjoying music and a sunny sky etc came back,during this time my erections were better when i tried to masturbate a couple of times but sesitivity was worse i would say and orgasm was none existent,i was supposed to run a 14 day cycle but on day 8 i felt a slight soreness in my throat which by day 12 was full blown cold and flu symptoms so i stopped the cream that day,it took a me a couple of weeks to get better so i decided to wait till the 1st of march before resuming treatment with the cream,so on 1st march i started again on the usual dose of 5mg per day,i tried it on my forearms,chest,throat area,stomache, and up my arse a few times to see which was best,i noticed when i put it on my throat area i would get the best energy feeling,anyway not long after i started again a very stressfull event happened in my life and my anxiety came on strong,also the top of my scalp was itching like crazy,i became extremely jittery and very very anxious,the worst of my life,it was so bad my arms and hands were shaking when making tea etc,and sexual problems became worse,so i quit the cream on day 7 of the second cycle,also my hair started falling out like you wouldnt believe,ive probably had around 4 years hair loss in a few weeks i would say,since then my anxiety continued to be severe,i have been suicidal, my sexual problems still worse, what i mean is libido went from 5% to absolute zero,penis sensitivity got worse, that went from 5% to zero, erection strength went from around 50% to around 30%,orgasm still none existent,then i got flu again,im just coming off the flu now and things are starting to feel like they did before i started with the cream,ive had a complete nightmare while trying progesterone cream and wont be touching the stuff again,maybe if it hadnt been for the stress in my life id be feeling a lot different now who knows,all i know is ive got a lot less hair on my head and am no further forward with pfs…

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#8

What dosage did you take and for how long?
5mg. 1 day
What kind of formulation did you take and how did you apply it?
I remember it was for women, and i applied it to the chest.
How did it affect your symptoms in detail?
The day i used i felt nothing. Then after quiting it my depression increased a lot, along with anxiety, and sexual sides (which had massively improved since my fin crash) also worsened a lot. It’s one month since i used it, and things have not improved. What i have felt during this days is very similar to my finasteride crash. It feels like i have destroyed all my improvements.
If you quit, please tell us why?
The day i quit i did it because i felt nothing.

#9

I’ve experimented with progesterone. First time i took i took it for 5 days and took 5-10mg transdermally. Progesterone has had mixed effects.

It made me feel worse initially. I noticed slowing of facial hair growth, felt sleepy alot of the time. BUT erections were much stronger than before and the look of my penis varied immensely on it. At times it would be loose and as it once was with proper strong erections which only with cialis I have achieved. But then at times it would be as before and a bit lifeless. Libido reduced whilst on it. I noticed a rebound about a week after stopping it. First few days off it increased anxiety like feelings and then felt good for a bit.

I then tried it for two more days with selegiline. First day was the best day i’ve had in a long time and then the anti-androgenic effects kicked in again. But then I noticed that the type i had contained saw palmetto extract so i stopped. Also noted some slight puffiness of nipples that subsided after stopping.

Overall it definitely does something.

I’ve ordered a saw palmetto free version and will compare the difference. I’m hoping it will improve erectile strength again and i hope the anti-androgen effects are not as severe. I also will take seligiline with it, and potentially some natural testosterone boosters to counteract the anti DHT properties of progesterone.

I found this article interesting: ncbi.nlm.nih.gov/pubmed/20009921

It might be too early to say but selegiline has boosted my overall feeling of well being and i’ve only been on it for about a week. I’ll let you know how things go.

#10

Definitely keep us up to date. I’m very interested in seeing how people respond to selegeline, with or without progesterone.

#11

i have been off the cream now around two months,i now have sides ive never had before,ive had constant pain in my balls but its getting less frequent now,also a pain in my pc muscle area,like behind your balls,almost feels like a blockage or something,this is also going away bit by bit,my mental sides have gone into overdrive,worst of my life infact,ive barely been hanging on to sanity lately,i have had a lot of life stress etc this year but i believe it was using the progesterone cream which made everything ten times harder, the stuff has put me back to my crash days six years ago,i feel fucked,the severe hair loss i experienced is starting to grow back believe it or not,i have hairs sprouting up allover the bald patch progesterone caused…

#12

That is what I’d be interested in too. Have any users actually tried this ALONE as a protocol?

#13

I don’t think so. I may give it a go at some point.

#14

What dosage did you take and for how long?
Approx 5 mg, just the one time.

What kind of formulation did you take and how did you apply it?
Eurovital (micronised).
Applied to skin - inner arms.

How did it affect your symptoms in detail?
Within a few hours I had developed flu-like symptoms: throat irritation, feeling congested, nauseous with a mild headache. It sent my tinnitus into overdrive - still hasn’t subsided.
Also made me sleepy.

Was it self-prescribed or did a doctor prescribe it to you? Did you do any labs?
Self-prescribed.
No lab work. One off self-test to see how I would respond. Won’t be trying it again.

If you quit, please tell us why?
See above.

#15

I should also add that it further decreased overall sebaceous activity, reduced the girth of my wiener, and stalled any erectile capabilities for several days. All from one tiny application.

#16

It is two and a half months since I quit the progesterone and I am absolutely fatigued every day now,definately back to my crash days,the pain in my balls has almost gone,just odd days im getting the odd slight ache now,libido still at zero,just so tired and weak,the stuff has wrecked me…

#17

I think it’s clear why progesterone could be bad for us. Since stopping my body has undergone a bit of a crash mainly sexually.

Progesterone is antiandrogenic. It reduces conversion or T to DHT and reduces Gnrh pulse freq and strength.

The interesting question is why is it helpful at first. Personally i had improvements with erections whilst on it that no other treatment had given. It could be for one of a number of reasons:

  1. Progesterone decreases DHT and therefore takes a load of a hypersensitive androgen receptor lifting a post translational modification

  2. Prog increases neurosteroids and helps repair a neuro endocrine deficit and potentially helping to relieve oxidative stress

  3. That both an increase in testosterone and progesterone derivatives increase substances like nerve growth factor which leads to functional recovery of AR up to a point

Problem with it is that by reducing androgens themselves it can lead to decreased output from the AR leading to more peripheral AR over expression so upon stopping can lead to another crash

To explore this the use of cerebrolysin would be interesting as it would explore the more neurological element as opposed to the endocrine one.

#18

I know this is an old post but it’s still stickied and I think gives unrealistic statistics on progesterone. No offense intended to the creator of the poll but there are five negative answers and one positive response that is somewhat unrealistic. It would be like me asking :

“What is your experience with propecia?”

A. It worked Ok but then gave me horrible side effects.
B. It has ruined my life.
C. It didn’t work and it has given me horrible side effects that are permanent.
D. It grew back all of my hair with no side effects and my dick is bigger too!

Obviously with this question you’ll get more negative answers than positive because the positive answer isn’t very realistic, I’m surprised there are even that many positive responses with the way the current pole is which I would say bodes very well for progesterone treatment. I could suggest adding these as they’re realistic outcomes to progesterone treatment (I have dosed with progesterone):

-There were up’s and down’s while dosing and although I’m not cured I feel better than when I started.
-I didn’t stay on it long enough to really give it a chance. (Less than three months)
-I’m currently dosing and believe I am headed in a positive direction based on how I feel.

#19

I tried progesterone alone 5mg a day i got alot worse.

Few months later i tried something abit differnt. I took one pill of clomid 50mg. For the next 7 days i felt horrible from the clomid, extreme estrogen feelings (i was on trt) so i decided to take progesterone 30mg a day. WIthin a few days my PFS reversed about 90% and i partied all month thought id cured it. Then once the clomid left my system i crashed with progesterone dominance.

Somehow clomid allows my DHT to work BUT clomid gives me a weird estrogen feeling that Ai cannot stop. But when i stack progesterone with it it opposes the weird estrogen and i recover.

Its just not sustainable however. Nothing is… but man 3 weeks of recovery was amazing… but it took 4 months after that crash to recover from the excess progesterone.

#20

I would like to relive this topic for more data on progesterone use.

Anyone?

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