PFS Institution The dream goal

General Discussion
#1

Guys if i win the powerball this week I’m gonna setup a pfs institute with a small chunk of interest of my money :moneybag: lol :laughing: :sweat_smile:

This would be a dream goal from pfs research and patients…

According to ai this would be the cost and how the setup works

:office: Structure of a PFS Institute

  1. Headquarters & Labs

A dedicated research center — either attached to a major university (for credibility) or fully independent.

State-of-the-art labs:

Genomics/epigenetics lab → sequencing, methylation studies, RNA analysis.

Cell culture + CRISPR lab → AR receptor work, neuronal/glial models.

Neurosteroid/biochemistry lab → hormone pathways, neurotransmitter assays.

Animal facility → rodent models to reproduce PFS features.

  1. Staff

Director: a respected MD/PhD in endocrinology or neurobiology.

10–15 core scientists (genomics, molecular biology, endocrinology, psychiatry, urology).

20–30 postdocs/technicians.

Clinical team for recruiting and running trials.

  1. Governance

Scientific advisory board: experts in andrology, neuroendocrinology, psychiatry, genomics.

Patient board: actual PFS patients advising priorities.

:microscope: Research Focus Areas

  1. Biomarkers → blood, CSF, or imaging markers that prove the condition objectively.

  2. Mechanisms → androgen receptor overexpression, epigenetic silencing, neurosteroid imbalance.

  3. Therapeutics → repurposed drugs, gene therapies, neurosteroid modulators.

  4. Clinical Trials → Phase I/II with real endpoints like neuroimaging, hormone panels, and validated scales.

  5. Data Hub → centralized biobank + patient registry for international researchers.

:moneybag: Budget Snapshot

Building/labs: $20M

Annual operating costs (staff + equipment + studies): $15–25M

Clinical trials: $5–10M each

With $250M endowment, it could run forever just off investment income — like how the Howard Hughes Medical Institute works.

:earth_africa: Global Impact

PFS would stop being a fringe “debated” condition.

You’d attract top scientists — prestige and steady funding always does.

Pharma would have to take notice (especially if you identified a druggable pathway).

You’d leave behind a permanent institution — something no lawsuit or PR campaign could erase

The current power ball is 1.3 billion so you would get around 600 million after taxes in a lump sum and setting it up the interest would be about 400k a week or 23 million a year…

So it would be easy…its a dream guys but thought its a fantasy thst might brighten somes spirits…

So see these multi millionaires and billionaires could easily fund an around the clock endeavor like this.

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#2

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Here’s our logo guys…

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#3

millionaires and billionaires wouldn’t give you a dollar if you were starving let alone fund something like this lol

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#4

You’re right about that lol…Well no one won…Now its 1.7 billion dollars and the lump sum payout is 770 million dollars…

Just imagine all the good in the world one person could do with just the interest off of 700 million dollars each month…it would do nothing but generate an never ending cash flow…

You lose over half that lump sum in taxes federal…Andvwe don’t even have Healthcare in this country and now its getting worse under the current administration…

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#5

:moneybag: Step 1: Lump Sum Estimate

Jackpot (annuity): $1.7B

Lump sum (cash value ≈ 60–62%): about $770 million

:moneybag: Step 2: After Federal Taxes

Federal tax (37% top bracket): ~$285 million

Net after federal: about $485 million

(State taxes could knock this down further depending on where you live, but let’s stick with the no-state-tax scenario first.)

:chart_with_upwards_trend: Step 3: Interest Income

Safe options at today’s rates (2025):

5% Treasuries (short-term T-bills):

$485M × 0.05 = $24.25M per year

≈ $2M per month

≈ $66,000 per day

4.5% high-yield savings/CDs:

$485M × 0.045 = $21.8M per year

4.0% longer Treasuries (10-year):

$485M × 0.04 = $19.4M per year

Perspective

Even at the lowest conservative yields, you’d still be pulling in ~$20 million a year just from interest.

That’s about $55,000 per day in passive income — without ever touching the principal.

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#6

Here’s the dream goal with limitless funds

:office: Phase 1: Founding the Institute

Land & Building

Research facility (labs + clinics + offices, ~60,000 sq ft): $40M–50M

Modern equipment (genomics sequencers, neurosteroid assay machines, CRISPR platforms, neuroimaging gear, etc.): $25M–30M

Secure biobank + patient registry IT infrastructure: $10M
Subtotal: ~ $75M–90M one-time setup cost

:woman_scientist: Phase 2: Core Operations

Staffing (annual)

1 Director (MD/PhD, global expert) = $1M

10 Senior Scientists (endocrinology, genomics, psychiatry, urology, neuroscience) = $4M

20 Postdocs / junior researchers = $2M

30 Lab techs & admin = $2M

15 Clinical staff (trial coordinators, MDs, nurses) = $3M
Annual payroll: ~ $12M

Operations & Research Budget

Consumables (reagents, animal facility, sequencing costs, assays) = $8M

Patient registry maintenance + biobank growth = $2M

Conferences, collaborations, travel, training = $1M
Annual ops/research: ~ $11M

Annual Burn Rate (staff + ops): ~ $23M

:microscope: Phase 3: Research to Treatment Pipeline

A. Biomarker Discovery (Years 1–3)

Deep epigenome + transcriptome mapping of 500–1,000 patients

Estimated cost: $10M–15M

Deliverable: validated biomarker panel (blood/CSF markers, imaging signatures) → official diagnostic test

B. Mechanism Elucidation (Years 1–5)

AR dysregulation, neurosteroid synthesis, gut–brain axis exploration

Animal models of PFS

Estimated cost: $15M

C. Therapeutic Screening (Years 3–6)

High-throughput testing of repurposed drugs (SSRIs, AR modulators, neurosteroid analogs)

Early CRISPR/dCas9 attempts for epigenetic reset

Estimated cost: $20M–30M

D. Clinical Trials (Years 4–10)

Phase I/II proof-of-concept = ~$5M each

Phase III larger efficacy = ~$25M each

Run 3–4 trials in 10 years = $60M–80M

:chart_with_upwards_trend: Totals Over 10 Years

Setup: $75–90M

Operations (10 yrs): $230M

Research Programs: $100–130M

Trials: $60–80M

:point_right: 10-year grand total: ~$450M

That’s almost exactly what you’d pocket from the lump sum — meaning you could fully endow the PFS Institute for 10+ years of cutting-edge research and clinical trials, without needing outside funding.

And if you only invested half ($12M at 5%)** could fund the institute indefinitely.

:white_check_mark: Bottom line: A PFS Institute with $250–450M behind it could:

  1. Establish PFS as a recognized, diagnosable condition (via biomarkers).

  2. Uncover mechanisms (epigenetic AR dysfunction + neurosteroid deficiency).

  3. Push candidate treatments through proper clinical trials.

  4. Provide real therapies within 10 years instead of patients waiting in limbo.

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#7

Here’s a small approach

The big number I gave just now ($75–90M setup) was for a standalone, state-of-the-art flagship institute — the “Howard Hughes / Broad Institute” model with its own campus, imaging suites, animal facility, etc.

Let me break it down cleaner:

:office: Setup Options

  1. Lean Model (attached to a university)

Renovated lab space: $10M

Equipment: $8–10M

Biobank + IT: $2M
:point_right: Total setup: ~$20–25M

This looks like a “specialized research program” inside an existing medical school (e.g., Tampere, Kiel, or Milan). Most rare disease foundations start this way.

  1. Mid-Size Independent Center

Purpose-built lab building: $40M

Equipment: $25M

Biobank + IT: $10M
:point_right: Total setup: ~$75M

This gives you your own identity and space, but still not a mega-campus.

  1. Flagship Institute (full standalone)

Modern research campus, clinical trial wing, animal facilities, conference center: $75–90M+

All equipment + infrastructure: $30M
:point_right: Total setup: ~$100–120M

This is the “dream big” version that would rival existing major medical institutes.

:balance_scale: Realistic Path for PFS

If tomorrow someone dropped $20–30M, you wouldn’t need a whole institute yet. You could:

Fund biomarker studies.

Build a biobank.

Run small trials (repurposed drugs, neurosteroid modulators).

And that could realistically deliver diagnostics + first treatment candidates within 5–7 years.

So yes — $20M is enough to start moving the needle, while the $400M+ estimate was for a decade-long, self-sufficient global institute with trials and its own labs.

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#8

Well 2 people won the 1.8 billion…Think one of them has pfs?