Pfs and Acetylcholinesterase

While studying the effects of pesticides on mental health, i noticed that the mental symptoms of op pesticides poisonings are identical to those of pfs.
Op pesticides act inhibiting the Acetylcholinesterase enzime, causing a build up of acetylcholine, causing anxiety, depression etc…
And yet, the ache (Acetylcholinesterase) inhibition from op pesticides can be irreversible (like pfs).
intrigued by the similarity between the two syndromes, I looked for studies about it but found only this.
From what I understand, finasteride inhibits the ache in some areas of the brain but not in others.
English is not my mother language, so I ask for your help to understand more.