periferic resistence hypogonadism

prop · May 25, 2018, 6:45am

lot of affinities with PFS, maybe we can call it iatrogen periferic resistence hypogonadism.
I have not find lot of info on web.

here anyone had qualitative and quantitative androgen receptor evaluation?
this is best test for dyagnose periferic resistence hypogonadism

Dubya_B · May 25, 2018, 6:45am

Do you mean something like this?:

Investigation of peripheral androgen resistance in genital hypoplasia associated with congenital growth hormone deficiency.
Lischka A.
Source

Department of Pediatrics, Ludwig Boltzmann Institute for Pediatric Endocrinology, University of Vienna, Austria.
Abstract

In a male infant with congenital growth hormone deficiency and genital hypoplasia (micropenis, cryptorchidism and small scrotum) androgen receptors, tissue specific 5 alpha reductase and steroid excretion pattern were determined in order to test the hypothesis of peripheral androgen resistance. A reduced number of cytosolic binding sites (Nmax) was found for the T and DHT receptor in patients foreskin compared to controls (n = 9) of similar age. The specific affinity (Kd) of the cytosolic receptor, however, was normal. Tissue specific 5 alpha reductase determination revealed a Vmax of 3.3 pmol/mg/h (controls 15.8 +/- 1.4). Analysis of urinary steroid excretion pattern revealed decreased levels of T metabolites, indicating impaired T metabolism. We postulate, that genital hypoplasia in patients with congenital GH deficiency is associated with impaired target organ responsiveness to androgen hormones caused by abnormalities within the pathway of intracellular reactions of T utilization.

Yes, I believe a few guys had a test done that measures the capabilities of their androgen receptors to bind androgens and the tests came back normal for all of them. I don’t think anyone here has had a quantitative test performed, but I could be wrong.

Can you provide a link to more information regarding perific resistance hypogonadism? I couldn’t find anything about it.

prop · May 25, 2018, 6:45am

as i said i found few info in italian
books.google.it/books?id=PycX8BxTBnkC&pg=PA97&lpg=PA97&dq=resistenza+periferica+ipogonadismo&source=bl&ots=l2iOX5wgXf&sig=Jl64N3vckQl9Yw8tJ0E66OtGau0&hl=it&ei=emA0Ts2jAYKXOoXf_foL&sa=X&oi=book_result&ct=result&resnum=3&ved=0CB8Q6AEwAg#v=onepage&q=resistenza%20periferica%20ipogonadismo&f=false

look at this summary p16 and 18 (unfortunately is in italian)

med.unipg.it/ccl/Materiale%20Didattico/Endocrinologia%20e%20Malattie%20del%20Metabolismo%20-%20canale%20A/Ipogonadismo%20maschile.pdf

in secondary hypo
u can see 3 kind perific resistance hypogonadism
-Complete (S. di Morris)
-Incomplete (S di Reifenstein)
-Deficit 5ar

i’m not deep in these things but i saw some interesting “new” tests among the common tests here (p 97 first link)

Dubya_B · May 25, 2018, 6:46am

Thanks prop. Wish I could read Italian though .

The question of whether or not we have some acquired form of androgen insensitivity has been discussed many times on this board in the past. (Do a search for “androgen insensitivity” in topic titles only and you will find about 11 threads devoted to this subject. Its pretty damn good reading if you have the time to spare.

The 3 forms of androgen insensitivity you mentioned are normally caused by genetic disorders and the members that have been checked for androgen insensitivity have all tested negative for mutations in the gene that encodes the androgen receptor. I’m not positive that anyone was tested for the 5ar deficient form of androgen insensitivity, but I am pretty sure it was assumed that this isn’t the cause of PFS since many guys have good levels of DHT in spite of having some bad symptoms. BTW: Finasteride was developed to mimic the 5-ar deficient form of pseudohermaphroditism.

The idea that I might have some type of androgen insensitivity has been haunting me since 2003 when an endocrinologist ran a slew of hormonal tests for me and they all came back well within normal ranges. When I begged her for an answer, she suggested androgen insensitivity syndrome but told me that would be impossible because it is something you must be born with, you can’t develop AIS during adulthood.