Remember that Finasteride upregulates TGF-B – propeciahelp.com/forum/viewtopic.php?t=588
[i]and induces prostate involution via cell apoptosis (death) – propeciahelp.com/forum/viewtopic.php?t=201
and also has been linked to reduced prostatic and seminal vesicle bloodflow – propeciahelp.com/forum/viewtopic.php?t=922
and has caused penile fibrosis (in rat) via lack of androgens (DHT) – propeciahelp.com/forum/viewtopic.php?t=59
Penile fibrotic changes after radical retropubic prostatectomy
FULL TEXT: blackwell-synergy.com/doi/fu … 00.00364.x
PDF: blackwell-synergy.com/doi/pd … 00.00364.x
Selected bit:
The aetiology of penile fibrotic change after RRP is unknown. The observation of penile shrinkage after RRP has been attributed to penile atrophy or fibrosis following denervation, and may be related to apoptosis, which has been observed after denervation in the rat penis.
This atrophy and fibrosis may result in further scar formation, leading to clinically apparent disease. El Sakka et al. showed that surgical trauma on the tunica albuginea caused a self limited increase in TGF-β synthesis but caused no clinically apparent fibrosis, suggesting that there is another yet unidentified mediator in the pathogenesis of this condition.
Another explanation may be related to Moreland’s report that hypoxia [lack of oxygen to tissues, due to lack of bloodflow] causes changes in human penile smooth muscle cells in tissue culture, resulting in penile fibrosis . The mechanism for such a reaction would probably involve TGF-β and the release of other inflammatory mediators by trapped leukocytes .
Finally, one of the more popular theories suggests that penile trauma is a major causal factor in the pathogenesis of Peyronie’s disease. It has been proposed that there is a local inflammatory response characterized by fibrin deposition, which is unmitigated and trapped within the layers of the tunica albuginea .