Penile anesthesia in PSSD responds to low power laser


Penile anesthesia in Post SSRI Sexual Dysfunction (PSSD) responds to low-power laser irradiation: a case study and hypothesis about the role of transient receptor potential (TRP) ion channels.
Waldinger MD1, van Coevorden RS2, Schweitzer DH3, Georgiadis J4.
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Treatment of paroxetine-induced penile anesthesia in Post SSRI Sexual Dysfunction (PSSD) by Low-power Laser Irradiation (LPLI) is unknown in medical literature. The aim of the current article is to report partial efficacy of LPLI for paroxetine-induced persistent penile anesthesia. We report on a male patient who presented with a history of reversible loss of smell, taste and skin sensitivity occurring within a week after start of 20mg/day paroxetine-hemihydrate for a depressive period. Concurrently, patient suffered from penile anesthesia, scrotum hypesthesia, anejaculation and erectile difficulties with normal sexual desire. During 2.5 years of paroxetine treatment and throughout 2 years after paroxetine discontinuation, genital and sexual complaints persisted. Penile anesthesia was treated by LPLI with single and multi diode pulsed laser probes. After 20 LPLI-treatment sessions of 15min each, patient reported partial return of penile touch and temperature sensation. Clinical improvement of glans penis sensitivity was reported to 20% and 40%, compared to pre-paroxetine treatment penile sensitivity during erect and flaccid states, respectively. However, anejaculation and erectile difficulties remained unchanged. Briefly, in the current patient with early onset of PSSD, LPLI treatment reduced paroxetine-induced penile anesthesia. It is hypothesized that SSRI treatment induces disturbances of transient receptor potential (TRP) ion channels of mechano-, thermo- and chemosensitive nerve endings and receptors resulting in the penile anesthesia in PSSD. It is further hypothesized that there are two types of PSSD, one of which occurs soon after the start of SSRI treatment.
Copyright © 2014 Elsevier B.V. All rights reserved.

#2 … d_2_(TRPV2_ion_channel

#3 … 980.f04t04

#4 … _2010a.pdf

Localization and Function of Cannabinoid Receptors in the Corpus Cavernosum: Basis for Modulation of Nitric Oxide Synthase Nerve Activity

#5 … 55346.html


Measom, M. O. (1992) Penile anaesthesia and fluoxetine. American Journal of Psychiatry, 149, 709.
↵ Neill, J. R. (1991) Penile anaesthesia associated with fluoxetine. American Journal of Psychiatry, 148, 1603 .


Ellison, J. M. & DeLuca, P. (1998) Fluoxetine-induced genital anaesthesia relieved by Ginkgo biloba extract. Journal of Clinical Psychiatry, 59, 199 -200.


regarding your first post, i think jthese transient receptor potential ion channels are very relevant for pfs pssd and cfs.maybe they are the root

we shoukd look more into them


Has anyone tried this laser?


I have. Hasn’t worked for me.