what’s up, you people may know that 5ar-1 is the main subtype in brain areas related to sexual development like mPoa
turns out this widely available supplement upregulates it by 97% even at very low dose
as well as increasing Allo/DHP and other neurosteroids
"Importantly, a single PEA EC50
dose normalized the expression of these proteins to the levels quantified in GH-control mice (PPAR-α: +109%, p<0.01; StAR: +339%, p<0.001; CYP11A1: +81%, p<0.01; 5α-RI: +97%,
This study provides novel neurobiological evidence that stimulation of PPAR-α by PEA induces the corticolimbic biosynthesis of Allo, an effect that is directly associated with the improvement of a PTSD-like phenotype in SI mice. Specifically, PEA reduced the expression of conditioned contextual fear, and facilitated extinction and extinction retention (Fig. 1). PEA also induced anxiolytic- and antidepressant-like effects in SI mice. Furthermore, the behavioral effects of PEA in SI mice related to normalization of down-regulated levels of Allo in hippocampus, amygdala, prefrontal cortex and the olfactory bulb. PEA also elevated Allo-S in the hippocampus"
and it seems like nobody has tried yet…