Has anyone had/has paranayodic attacks about stuff? such as, someone is playing with my mind / Nobody actually believes me etc’…
I try to shake it off sometimes and do constructive stuff but sometimes the mental effects are too overwhelming…
Yes, i had that. In my opinion it is dopamine deficiency. Now, if this deficiency is caused by low hormones, depression or some other effect from propecia i don’t know.
The same neurosteroids that Fin interferes with are also involved in mental disorders like schizophrenia.
This study suggests that Allopregnanolone increases dopamine release and dopamine response. So, if we are low on allopregnanolone, we are low on dopamine as well:
ingentaconnect.com/content/b … .alexandra
So, being low on dopamine, we get a minor feeling of reward from any experience. Neurotransmitters work together and in a cascade effect. When you raise dopamine you raise other neurotransmitters with it (including GABA).
So, in my opinion if we are able to increase dopamine alone, we will in consequence increase GABA, reversing the effects of having low allopregnanolone.
The problem with antidepressants like Wellbutrin is that it also stimulates Noradrenaline. Noradrenaline makes you agitated erasing any benefit raised Gaba would give you.
I have been observing the foods i crave for the past months. This is important because desire for an specific food, shows your body might be deficient in some nutrient. Since the begining of this whole propecia mess in my life, i started drinking a lot of diet coke, eating a lot of chocolate and also a lot of cheese. Many times i used these to feel better. This week i learned these foods are rich in phenylalanine, which is a precursor of Dopamine. For me this is proof that i am deficient in dopamine because of propecia.
As my endo thinks it is strictly neurological but has no idea what might be causing this is it the problem with the dopamine receptor, allopregnolone receptor, neutrotransmitters supply or something else. There was something in the test Mew presented that rapid changes in the neurotransmiters output may disregulate receptors dedicated to them… right? I think many people are in trouble here becase of going on and of this drug many times. This is what I read here many times. This would exactly match this neurosteroid receptor theory. What do you think?
I think it is a supply problem.
Progesterone --> 5 ar convertion into allopregnanolone --> Gaba and Dopamine
I think we re still missing the second step… (will it ever recover totally?). I just posted a theory about this at the Theories section. Even if dopamine receptors have a role on this, it would only mean that we need an even higher dose of supplementation.
Maybe you are right. The funny thing is that I always had testosteron level in the middle-low range with great libido. No it is very high with now almost no libido at all. I wonder why this testosteron level is so high right now and the only thing that I can imagine is that there is less testosteron converted by the 5 alpha reductase. Maybe this is a mixture supply and receptor interaction. It is kind of funny that there was no studies for this problem as there seem to be a lot of people suffering from this.