Interesting article I came across… btw, GHB (Xyrem) increases Oxytocin - http://www.biopsychiatry.com/ghb/authentic.html
Oxytocin increases 5-reductase activity of human prostate epithelial cells, but not stromal cells
Oxytocin is known to modulate 5–reductase expression and has, therefore, been implicated in the etiology and novel pharmacological treatments of benign prostatic hyperplasia (BPH). These suggestions have been made in the absence of any direct evidence that oxytocin regulates expression or activity of 5–reductase isoenzymes in the human prostate. This study evaluated the effects of oxytocin on the activity and expression of 5–reductase isoenzymes I and II of human prostate stromal (PrSC; primary site of BPH development) and epithelial (PrEC) cells.
Cell cultures were incubated with oxytocin, or oxytocin plus a specific oxytocin antagonist for 24 hr, and conversion of 3H-Testosterone to dihydrotestosterone used to estimate total 5–reductase activity and to determine activity of both type I and type II isoenzymes. Fully quantitative real-time RT-PCR determined levels of expression of both isoenzymes following treatments.
Oxytocin significantly increased the total 5–reductase activity of PrEC but not of PrSC. 5–Reductase I gene expression and enzyme activity were also increased (P < 0.05) in PrEC by oxytocin. Oxytocin significantly increased type II activity, but not expression, in PrEC. Oxytocin did not significantly affect 5–reductase activity or expression in PrSC.
Both 5–reductase I and II are expressed in normal human prostate stromal and epithelial cells. Only 5–reductase isoenzymes of prostate epithelium are modulated by oxytocin. Prostate 68: 115-121, 2008. © 2007 Wiley-Liss, Inc.