Only read the abstract, but this is interesting. https://onlinelibrary.wiley.com/doi/abs/10.1111/andr.12824
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Exactly Obesity-Induced (Which 99% of us isnt), and it does that by making those ppl lose weight. Sadly nothing that might help us.
This could potentially be a fat loss drug for bodybuilders?
Says also improved fertility for men
Interesting
Studies have demonstrated that the absence of endogenous leptin is associated with hypogonadism,53,54 yet, high leptin level is reported to suppress steroidogenesis.54 Human and experimental studies have linked significant decline in testosterone level, impairment in sperm count and motility, and increases in sperm abnormal morphology and DNA fragmentation, with high leptin levels.
55-57 In fact, experiments demonstrated that exogenous leptin administration impacted negatively on sperm parameters in rats,58,59 thus raising concerns about leptin levels in subfertile/infertile obese men. This important association was observed in the present study as leptin level correlated negatively with testosterone level and sperm motility but correlated positively with sperm nDNA fragmentation, thus confirming the fact that high leptin levels may hamper fertility potential. The decreased testosterone level may be as a result of the inhibitory effect of leptin on SF-1, StAR and P450scc genes which are necessary for steroidogenesis.54 In the present study, the administration of orlistat significantly decreased leptin level in the treatment groups, with the preventive group (HFD+Opr) showing a better response. Our findings corroborate previous studies,14 which reported that orlistat decreased obesity related co-morbidities by decreasing leptin and increasing adiponectin level independent of body fat and waist circumference.
It also states that adipose tissues secrete leptin and that too high (or too low) leptin levels lead to dysregulated gene expression of steroidogenic enzymes, however as bolded above orlistat seems to decrease leptin levels independent of BF/waist circumference.
The link between leptin level and male subfertility has long been identified, and studies have demonstrated that a tight regulation of the hormone is important in preserving male fertility. Studies have demonstrated that the absence of endogenous leptin is associated with hypogonadism,53,54 yet, high leptin level is reported to suppress steroidogenesis.54 Human and experimental studies have linked significant decline in testosterone level, impairment in sperm count and motility, and increases in sperm abnormal morphology and DNA fragmentation, with high leptin levels.55-57 In fact, experiments demonstrated that exogenous leptin administration impacted negatively on sperm parameters in rats,58,59 thus raising concerns about leptin levels in subfertile/infertile obese men. This important association was observed in the present study as leptin level correlated negatively with testosterone level and sperm motility but correlated positively with sperm nDNA fragmentation, thus confirming the fact that high leptin levels may hamper fertility potential. The decreased testosterone level may be as a result of the inhibitory effect of leptin on SF-1, StAR and P450scc genes which are necessary for steroidogenesis.
It’s an overly generalizable point, but FWIW it may help to stay at a healthy body weight. Or moreso decrease BF percentage to a good range.
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That would be nice
I work my ass off to stay very lean haha