Oral DHEA for increasing Adiol G

Science Other Studies
#1

Found this study: Oral DHEA can increase Adiol G

[Abstract:]
Fertil Steril. 2004 Mar;81(3):595-604.

Pharmacokinetics of dehydroepiandrosterone and its metabolites after long-term daily oral administration to healthy young men.

Acacio BD, Stanczyk FZ, Mullin P, Saadat P, Jafarian N, Sokol RZ.

Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

OBJECTIVE: To determine the effects of dehydroepiandrosterone (DHEA) supplementation on the pharmacokinetics of DHEA and its metabolites and the reproductive axis of healthy young men. DESIGN: A prospective, randomized, double-blind, placebo-controlled pharmacokinetic study. SETTING: General Clinical Research Center and laboratories at the Keck School of Medicine of the University of Southern California, Los Angeles, California. PATIENT(S): Fourteen healthy men, ages 18-42 years. INTERVENTION(S): Daily oral administration of placebo (n = 5), 50 mg DHEA (n = 4), or 200 mg DHEA (n = 5) for 6 months. Blood samples were collected at frequent intervals on day 1 and at months 3 and 6 of treatment. MAIN OUTCOME MEASURE(S): Quantification of DHEA, DHEA sulfate (DHEAS), androstenedione, T, E(2), dihydrotestosterone (DHT), and 5alpha-androstane-3alpha-17beta-diol glucuronide (ADG). Physical examination, semen analysis, serum LH, FSH, prostate-specific antigen, and general chemistries were carried out. RESULT(S): Baseline DHEA, DHEAS, and ADG levels increased significantly from day 1 to months 3 and 6 in the DHEA treatment groups but not in the placebo group. No significant changes were observed in pharmacokinetic values. Clinical parameters were not affected. CONCLUSION(S): DHEA, DHEAS, and ADG increased significantly during 6 months of daily DHEA supplementation. Although the pharmacokinetics of DHEA and its metabolites are not altered, sustained baseline elevation of ADG, a distal DHT metabolite, raises concerns about the potential negative impact of DHEA supplementation on the prostate gland.

Please discuss!

#2

Since DHT levels were unchanged and Adiol G levels increased, it seems that more DHT was being metabolized in the liver. However that also doesn’t make sense since if Adiol G levels increased you would also expect an increase in DHT. Ok here’s my third guess, possibly 5ARII activity increased, which increased the DHT, but the add’l DHT was metabolized which caused DHT levels to remain constant and Adiol G levels to increase. In this last case I think this would help us.

Not sure what they mean by "sustained baseline elevation of ADG, a distal DHT metabolite, raises concerns about the potential negative impact of DHEA supplementation on the prostate gland. "

#3

I posted this study a while ago. The above just means elevated 3-Adiol-G levels might have a negative impact on the prostate, since most DHT is metabolized there. DHT levels have traditionally been implicated in BPH as a result Proscar was created to combat it.

#4

okay

but the point of me posting it is if ppl are so happy to increase their adiol g levels dhea supplementation might just do

combined with something like arimidex to counter conversion into e2 it should surely go to dht and adiol g

#5

kwakka,

Good point that DHEA supplementation can lead to increased estrone and hence estradiol. Nonetheless, I am trying 5 mg sublingual twice a day.

kazman

#6

Interesting…Maybe taking a high dose of DHEA per day(100mg?) along with some armidex…could help?

#7

annon1, would recommend reading Ray Saheian’s site about DHEA before ingesting 100 mg doses - he has studied DHEA for a long time. That high a dose has the possibility of sharply raising blood pressure.

www.raysahelian.com/dhea.html

Sublingual has much better bioavailability.

Hope this helps - kazman

#8

Your Better off taking the oral solution from Primordial Performance called Demacrine. With the new Liqua-vade technology, this stuff starts working fast, real fast. It’s the same technology used in the oral form of Sustain Alpha, which I have been taking in rotation with all of my other supps. I can literally feel more adrogenic in mere minutes. Perfect before hitting the weights.

#9

Thanks CD. I’ve noticed when I take 25 mg of DHEA per day along with 25 mg of prenolnone, I feel like I have more energy in the morning and I don’t have much trouble waking up…

#10

i am on doctor’s orders taking dhea 5 mg twice daily

i used to have the same dhea from same pharmacy 30 mg strength and after continuous use for a week i can sometimes start feeling itchy in the scalp

i also get zits

these are to me classic markers that dht is increased

is this the correct dht we need? i don’t seem to feel libido effect as it for certain increases my estradiol too much

perhaps indeed taking dhea along with estradiol blocker would counter conversion into estradiol and increase dht

guys… is this the correct place in the body where we need dht? i mean, if i feel my scalp tingling, can i assume the dht will be good for sexual function/wellbeing overall as well?

#11

Do not trust this Guy (Ray Sah…). He claims long term use of Saw palmetto does not cause any adverse effect although on his own website many people complained about Gyno after Saw palmetto usage.