Oral administration of all-trans retinoic acid suppresses experimental periodontitis by modulating the Th17/Treg imbalance

Still looking at this. idk theres a chance I could be right about this one.

Retinoic acid stimulates blood flow and promotes the formation of vascular tissues (angiogenesis) as well as lymphatic tissues and cells. As a result, there is a greater capacity for the surrounding periodontal tissues to be nourished; cell mediated immune responses occur more readily; and toxins and irritants may be carried away more quickly.

Looking at some patents again.

Method of treatment for periodontitis


A method of treatment for periodontitis comprises the topical or systemic administration of a pharmaceutical composition containing at least one retinoid compound other than Vitamin A. Preferred retinoids include Vitamin A aldehyde, Vitamin A acid, Vitamin A esters, isotretinoin, etretinate and acitretin.

Treatment of periodontoclasia with retinoic acid


Methods of retarding and reversing periodontoclasia and gingivitis and disorders of human gingiva over 60 years of age comprise topically applying to human gingiva retinoic acid in an amount effective to retard and reverse periodontoclasia and gingivitis where said amount is insufficient to be excessively irritating. An emollient vehicle, a toothpaste and a liquid rinse facilitating the same methods are included.