Number of Androgen Receptors Increases After Finasteride Use

[lbv]

Quote from the PFSFoundation:

A group of Italian researchers gave finasteride to rats and noticed that the number of androgen receptors in their brains went up. Moreover, the effects persisted long after the drug had been discontinued… [T]hey then called in men with PFS, took skin from the penis and found that the density of androgen receptors in men with PFS was about twice that of those without. Now, remember the idea of the testosterone bell curve and damping effects (little testosterone, little growth, more testosterone, more growth, even more testosterone, reduced growth)? I think this is what we are seeing here. With a greater concentration of receptors, the organ becomes more sensitive to testosterone and at a certain point, paradoxically, that sensitivity may shut down.

— Charles J. Ryan, M.D., Distinguished Professor of Clinical Medicine and Urology at the University of California, San Francisco

So the body does create new receptors, that’s its response to remedy the problem after using finasteride. But it has no remedy to how those receptors share the testosterone/DHT distribution.

I wonder if there will be a new drug to combat how many receptors are created after using fin, like a drug limiting the body from making too many. If that’s even the problem, it could be a lot more complicated than “there are too many receptors.”

[lbv]

I wonder if there’s a way to destroy some androgen receptors manually, maybe then the body wouldn’t create double the amount like it does with finasteride. I know things like too much ejaculation weakens the receptors but I don’t know if it destroys.

Maybe something like excessive alcohol or another substance does. I read that marijuana blocks DHT/AR activity, but it’s really weak so maybe it would have to be done a for a long time. Being an alcoholic would be too troublesome but I wouldn’t mind being a stoner for a year or so if it meant I’d get better. I’m just theorizing though.

[holyhead]

This now I think is believed to be the root cause of PFS…Increase and over expression of the androgen receptor leading to a type of shut down or insensitivity to androgens once they return to normal levels…From there many different down stream effects happen…

[lbv]

I wonder how over expression works with this knowledge. Does the flood of DHT after two weeks of cessation of finasteride really damage all those receptors? You’d think if there were more receptors they’d be able to handle the extra DHT.