Very interesting. I briefly looked over the article, will read it in full depth when I have time.
It’s funny though because just the other day when I was trying to interpret why the 2nd most overexpressed cluster of genes was "“metabolism of RNA” in the Baylor study meant.
And while I was searching I got actually got to read a little bit about these RNAi (RNA interference). Apparently they are able to suppress over 60% of our protein coding genes.
- Friedman et al. estimate that >45,000 miRNA target sites within human mRNA 3′UTRs are conserved above background levels, and >60% of human protein-coding genes have been under selective pressure to maintain pairing to miRNAs. Direct experiments show that a single miRNA can reduce the stability of hundreds of unique mRNAs."
Unstable RNA leads to increased RNA metabolism, so that was the link I found to Baylor. They do not discuss that cluster at all in the paper so I have no clue if it’s related.
But I find it reasonable. Also worth nothing HDAC inhibitors only regulate about 2% of our genome. Quite the difference in potential impact.