I also look at this article
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Have you looked into seeing if its possible to get an immunohistochemistry test done?
It measures receptors but mainly for breast cancer. I wonder if these specialists could use there clinical expertise to give us a diagnosis.
I did a simple search on it, I ask you because you seem to have a good line on getting testing and knowledge and drive.
Hmm
It sounds like it’s right up my ally
Getting the ZRT urine neurotransmitter testing down to a science has been a full time job in of its self to be honest. But what you are mentioning with the immunohistochemistry testing does interest me. We would have to start by calling the labs that offer the testing. Sounds simple but it’s a lot of work
They may say that it’s for research purposes only to be sold to research institutions. But only one way to find out
I think that if more people step up and do the urine neurotransmitter and metabolite testing and if we keep seeing high Allopregnanolone and low glutamate that this could push someone like Melchangi to do a CNS neurotransmitter study with a PFS and control group. Personally this is what I want
So far 5 out of 6 people have high urine Allopregnanolone. The 6th person who did not have high urine Allopregnanolone is PAS. Not PFS. The 5 people with high urine Allopregnanolone are either Fin or Saw P PFS cases. Of the three that also tested urine neurotransmitters in addition to urine Allopregnanolone all three had low urine glutamate
Obviously we don’t know it these urine tests will reflect the CNS levels. But clearly we are seeing patterns in the urine
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Interesting study linking Pregnenolone-progesterone-allopregnanolone pathway and Schizophrenia:
“Firstly, at baseline, levels of PREG were significantly higher and those of ALLO were lower in FEAN-SZ than in HC, whereas PROG, cortisol, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) were not different. Consequently, the molar ratios of ALLO/PREG and ALLO/PROG in FEAN-SZ were significantly reduced. Secondly, in response to APD at 1 month, ALLO levels in FEAN-SZ were markedly elevated, whereas PREG and PROG levels decreased. Thirdly, among FEAN-SZ, lower levels of PROG (reflecting higher conversion to ALLO) at baseline may predict better therapeutic outcome after 1 month of APD treatment.”
https://www.sciencedirect.com/science/article/pii/S0306453017314488