A quick update.
Last year, I took a breath test for SIBO/IMO. It showed a slight overgrowth of methanogens. My result was 16 ppm, while overgrowth starts at 10 ppm. So I began a several-week treatment regimen using allicin (Allimed 2700 mg daily), neem (approx. 1200 mg daily), oregano (50 mg daily of oregano oil ADP), biofilm disruptors (Kirkman Biofilm Defense 2 capsules daily and NAC 600 mg daily), and glutamine (5 grams daily).
The treatment proved effective, as my methanogen levels decreased to 5 ppm. However, I developed hydrogen-producing bacterial overgrowth, with a result of 25 at the 80-minute mark of the test—a result on the lower end of the range. I was informed that the appearance of hydrogen-producing bacteria overgrowth after curing the methanogen overgrowth is normal, because previously this overgrowth was hidden due to the fact that methanogens were consuming the hydrogen-producing bacteria.
So this year, I started the next phase of treatment. This time, my protocol included glutamine (5 grams daily), Kirman Biofilm Defense (2 capsules daily), Allimed (1350 mg daily), and berberine (400–1200 mg daily).
And I had a big problem with berberine. I started with a dose of 1200 mg of berberine sulfate daily, and in the first few days, my mind was clearer, my depression was significantly reduced, and I also had a pretty strong libido.
As the days went by, not only did this effect begin to fade, but I also started experiencing severe anxiety, significantly worse brain fog, a steadily declining libido, and I began to gain fat around my stomach and nipples. Over time, these side effects became so severe (especially the anxiety, which was incredibly intense, comparable to my anxiety after the first finasteride crash) that I reduced my daily dose of berberine to 800 mg and later to 400 mg. I finished the treatment this week; I probably no longer have SIBO/IMO, but the aforementioned side effects of berberine are still quite severe.
Basically, while taking berberine, I felt the same way I did while taking finasteride. At first, an unusually strong libido, and then a descent into hell. All in all, this is no surprise, because berberine is a (quite potent for a natural remedy) reductase inhibitor, although it works on a slightly different principle (but it’s still a 5ARI).
In any case, I’d like to warn you about berberine. I don’t feel like it’s going to block me for long, but it’s worth being aware of its potentially destructive effects on us.
Oh, and one more thing. While experimenting with SIBO/IMO treatment, I discovered partially hydrolyzed guar gum (PHGG), which is a fantastic (at least for me) prebiotic that, in my case, radically improved the appearance and consistency of my stools as well as the frequency of my bowel movements.