New Insights into the Androgen-Targeted Therapies and Epigenetic Therapies in Prostate Cancer

This article provides a good summary of the structure and functions of the androgen receptor protein in section 2.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196248/?tool=pubmed#sec2

Section 4 describes the actions of the much-discussed HDAC and Methyltransferase enzymes, as well as a few other epigenetic factors, going into more detail to explain how manipulating the different isoforms of HDAC effects the transport and shape of the androgen receptor and also its ability to interact with androgen response elements and express gene products.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196248/?tool=pubmed#sec4

This diagram makes it much easier to understand some of what is being discussed in the article.

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