New blood test results

What do you guys make of this. I have been on TRT in a compounded cream for 5 weeks at 50mg of testosterone. Here are my blood test results:

Testosterone: 46 nmol/L ref 10 - 33)
Free Testosterone: 146 pmol/L ref (60 - 130)
Oestradiol: 119 pmol/L ref (40 - 250)
FSH: <2 U/L ref (3 - 20)
SHBG: 36 nmol/L ref (13 - 71)

DHT and LH are still pending.

What do you think is going on here? Obviously the T is too high but im on such a small dose. My libido is still crap. I wonder if im converting to too much E. Its strange that I am that high on such a small dose of T.

Any ideas?

What have you been prescribed and how long have you been on it?

When were the bloods taken?

How did you feel when the bloods were taken?

Do you feel any changes since the bloods were taken?

Mention any changes you have noticed…

I am on a compounded cream 10% with 5% Chrysin. Ive been on that for 4 weeks at 500mg which is 50mg of testosterone.

Bloods were taken at 10am. 2 hrs after cream application.

I felt no libido or drive when the bloods were taken. Not particulary energetic or anything either. Not good i guess. Voice was very deep at that point.

I dont really notice any difference since the blood tests other than the pitch of my voice goes from deep to high. Usually (not all the time) when my voice is deep I feel ok, but still no libido.

Also when ive just applied the cream somtimes I get very aggitated and want to fly off the handle.

I dont understand how my T could be so high, with E in range, yet I still have no libido. I should be rooting like a rabbit.

I havnt got a DHEA level, though I am taking 25mg per day in the morning and 2xDIM (Indolplex).

Well first of all testosterone is too high and that can cause feeling of wanting to “fly off the handle”.

So you want to get that in range by working with your endocrinologist to find the right level for you.

If these bloods were taken when you have only just gone onto TRT then I would not use them for altering the dose because you can expect the HPTA negative feedback and the effect of aromatase and estrogen conversion to alter those numbers and you need to alter meds based on steady state numbers.

When you have been on the gel for a couple of weeks then you could take the numbers to be steady state and base dosing on that.

When you have reached that point where you can dose for good numbers that feel best from a symptomatic point of view after a few weeks;

I would not expect libido to just click back into place, this is not turning on a light switch.

Libido can take months on the right dosage and hormonal levels to come back for some men.

You want to keep taking the hypogonadal checklist and see how you fair on it with the passing of time. Hopefully you will generally start feeling better in yourself and libido will come in time.

If you do not find a level of medication that you feel well on then you have to start considering various matters.

Is DHT a problem?

Is estradiol/estrogens a problem?

If you get very emotional and a tender chest- sometimes feeling like the chest is tingling and seeming to grow that would suggest possible gynecomastia development and irrespective of the pathology numbers that would mean that your estradiol is possibly too high for you.

If this is the case and DHT not low and fre testosterone quite good then you ned an endocrinologist who will consider small amounts of an aromatase inhibitor.

If none of this works you may consider differing forms of TRT. I have known men do very badly on one form of TRT and great on another, it is very much a case of horses for courses.

If you reached a stage where TRT fails irrespective of dose, form and ancillary meds then you can consider HCG, Clomipehene or even an aromatase inhibitor alone to see if any of those lead to symtomatic improvements, well-being and the return of libido.

You have to start somewhere and you have, this could be quick and easy or it could be very difficult. Time and experience with these problems has suggested it maybe the latter.

Yes I agree with everything you have said Hypo. It is a balancing act that will take time.

With the gyno, I have though my chest has gotten tingly, like Ive got a mild form of gyno. There is no growth at all, nor are my nipples tender, but the whole chest are gets tingly especially when im wearing a t-shirt.

I would love to try armidex to see what would happen. Gotta work with my doc for now though and see what happens. And if it came to trying armidex, I just hope i can get ahold of it, as in, I can find a doctor who will prescribe it.

Does it matter that ive got Chrysin mixed in, which is an E inhibitor? Does Chrysin really work?

Thanks for your help Hypo. Anyone else feel free to chime in too.