Interesting read if yall are interested. Apparently high progesterone can cause a disturbance in SERT which disregulates seretonin receptors in the brain. As with PSSD sufferes apparently PFS studies showed high progesterone levels too. Apparently estrogen is suppose to help counteract the effects of high progesterone. one suffer even had a mini recovery after taking exogenous estrogen. Could this by why NSAID(known aromatase inhibitor) use has been know to correlate with worse PFS symptoms? Many members have experienced extreme worsening of symptoms as a result of ingesting prescribed aromatase inhibitors.