the problem with PFS is your total and free T keeps dropping (or at least it happened with me) and you keep shedding muscles unless you check it. I said many times before I use vitamin D3. This is my only remedy. undoubtedly this is God send for me other wise I would have died. I still have tough times.My feet and thin bones are my biggest problem.
Hi everyone, I believe in two fundamental things regarding PfS. The first being that all of our symptoms are indicative of estrogen dominance (objectively proven by symptomology) and the second that undeniably whatever occurred with us happened at the neurosteroid level, presumably inhibiting the conversion of progesterone to allopregnanalone (proven by what finasteride actually can do) These theories are not mutually exclusive in other words whatever possibly could happen with progesterone would lead to estrogen dominance. They are enormous keys to this whole problem and I was excited to see Awor’s update about the success of the neurosteroid studies. I have struggled with how this is possible. My theory had always been that the inhibition lead to low levels of progesterone and thus estrogen dominance. However many of you reported higher than normal levels of progesterone and minimal effects of adding progesterone and some worsening affects. Tonight I spoke with my brother who is one of the best surgeons in this country, he is also a clinical genius. He told me that my logic was wrong, that in fact inhibiting the production of allopregnanalone would clinically raise the production of its precursor which is progesterone!! Since the progesterone is suppose to be converted to allopregnanalone but is not, it would increase in your system. Ok this explains why many of you reported high progesterone levels but it didn’t explain why it wouldn’t raise the progesterone effects and thus wipe out estrogen dominance. He then told me that progesterone is a down regulator of…progesterone!! That higher level reduce the sensitivity of progesterone receptor sites! So is it possible of both reduced allopregnanalone production (headaches, anxiety, brain fog) combined with higher levels of progesterone which down regulate the receptor sites (estrogen dominance, low t, etc)
Have you considered making an appointment with Dr. Michael Irwig to discuss this with him? I would recommend doing so as I read that he too believes the problem is in the brain.
Did your brother indicate as to how someone may go about treating this? Is there anyway your brother can get involved with the studies is he’s such a great clinician? I would assume he’d want to help his own brother out (as well as many other men).
No he can’t really go as far as recommend treatment protocols because that is not his area of expertise, however he works for a university medical center so I am going to try to arrange a meeting with the chief of the endocrinology department. He did indicate that 1) inhibiting one hormone will increase another and 2) progesterone can down regulate progesterone receptors. He believes it has to do with progesterone/estrogen ratios in the brain. Do any of you guys know your estrogen to progesterone ratio?