The erection of the penis during sexual excitation is mediated by the Nitric oxide (NO) that is released from nerve endings close to the blood vessels of the penis. NO also regulates adrenal function and endocrine function.
Your adrenal glands, located just above your kidneys, are responsible for the “fight or flight” response during an emergency. This is caused by the hormone adrenaline, also called epinephrine. The adrenal cortex is the outer portion of your adrenal gland responsible for making two steroid hormones. Cortisol and aldosterone affect your blood pressure and response to stress. Sometimes the adrenal glands make insufficient levels of cortisol. Certain vitamins can have an impact on the symptoms of this condition.
Adrenal Insufficiency
The adrenocorticotropic hormone is produced in your pituitary gland. This hormone signals the release of cortisol. Low cortisol levels can occur from two causes, when there is insufficient adrenocorticotropic hormone or not enough cortisol. Addison’s disease is an autoimmune disease that destroys the adrenal glands and leads to low cortisol levels. Chronic infections, adrenal cancer and other conditions can also cause low cortisol. Symptoms include fatigue, poor appetite, low blood pressure, nausea, dizziness, darkened skin and muscle spasms.
Inflammation Markers
When cortisol is released in response to stress, inflammation occurs. High cortisol levels are associated with high homocysteine levels, a marker of inflammation. Vitamin B-12 helps control inflammation by converting homocysteine to methionine, an amino acid. A 2006 study in “Clinical Chemistry and Laboratory Medicine” found that when subjects were supplemented with adrenocorticotropic hormone or cortisol, their homocysteine levels stayed the same. Serum B-12 concentrations became depleted, however, suggesting that the effects of high cortisol on inflammation can be buffered by vitamin B-12. This process will eventually deplete your levels if you do not replenish B-12.
Low Cortisol
Because vitamin B-12 helps reduce the effects of cortisol, low cortisol levels will likely require less vitamin B-12 from your body for this purpose. The benefits of adequate vitamin B-12 may help with some of the other symptoms with low cortisol. Vitamin B-12 is responsible for forming healthy red blood cells. Low cortisol decreases circulation by causing your blood pressure to drop, so it is important to avoid anemia, as not to impair blood cell functioning. Vitamin B-12 can also help reduce fatigue, another common symptom of low cortisol levels.
Adequate Nutrition
If you have low adrenal cortisol levels, you are at greater risk for malnutrition because your appetite is affected. While vitamin B-12 can be beneficial for high cortisol, it may also help with some of the symptoms of low cortisol levels. If you take too much supplemental B-12, you may mask a folate deficiency. The recommended dietary allowance is 2.4 micrograms per day. Rather than only supplementing with vitamin B-12, take a multivitamin to boost your overall nutritional status. Talk to your doctor about the possible benefits of dietary supplements with low cortisol levels.
Read more: livestrong.com/article/547250-b12-for-low-adrenal-cortisol/#ixzz22XgMJyxh
Effects of low cortisol
shaky hands; shakiness
diarrhea
bad palps
higher heart rate
pounding heart
feeling of panic
weakness
inability to handle stress
inability to handle interactions with others
inability to focus
rage or sudden angry outbursts
emotionally hyper sensitive
overreacting
highly defensive
feeling paranoid about people or things
exacerbated reactions to daily stress
no patience
easily irritated
mild to severe hypoglycemic episodes
nausea in the face of stress
taking days to recover from even minor stress
taking days to recover from a dental visit
flu-like symptoms
headache
all over body ache
super-sensitive skin
extreme fatigue
scalp ache
hyper feeling
jittery
clumsy (drop things, bump into things)
confusion
suddenly feel extremely hungry
low back pain
dull
cloud-filled head (happens when this patient is due for a next cortisol dose)
jumpiness
muscle weakness
“air hunger”
dizziness
light headedness
motion sickness
coffee putting patient to sleep
vomiting even running up the slightest incline
almost passing out every time patient gets up
dark circles under my eyes
waking up in the middle of the night for several hours
difficulty falling asleep
frequent urination
IBS symptoms
worsening allergies
Propeciashiz’s comments
Yes people have had injections of cortisol, why do they feel shit when taking it. Cortisol reduces androgens.
Posting this type of stuff from other websites does not really make any difference and simply clutters up the forum. Pls refrain from doing this over and over. Thanks.
p.s sorry mew, i’ll keep my posts in the one thread.
Some intresting info on Neurosteroids and finasteride
Neuroactive steroids modify neuronal excitability through interaction with neurotransmitter-gated ion channels (non genomic effect). In addition, these steroids may also exert effects on gene expression via intracellular steroid hormone receptors (genomic effect).
The chemical structure of endogenous 5alpha-pregnan-3alpha,21-diol-20-one (3alpha,5alpha-THDOC) and synthetic (alphaxalone, ganaxolone and 3alpha,5alpha-17-phenylandrost-16-en-3-ol, or 17PA) steroids. b | Biosynthesis of GABA (gamma-aminobutyric acid)-modulatory neurosteroids. The pathway for the synthesis of 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THPROG) from cholesterol is shown. Also indicated is the site of action of drugs that have been used to evaluate the influence of endogenous 3alpha,5alpha-THPROG on inhibitory neurotransmission. Steroidogenic acute-regulatory protein (StAR) might interact with the mitochondrial benzodiazepine receptor (MBR) to facilitate the transport of cholesterol across the mitochondrial membrane. 3alpha-HSD, 3alpha-hydroxysteroid dehydrogenase; 3beta-HSD, 3beta-hydroxysteroid dehydrogenase; 5alpha-DHPROG, 5alpha-dihydroprogesterone; P450scc, P450 side-chain cleavage.
I guess that explains my low adolestone cause of Deoxycorticosterone.