My experience leads me to think that many of us have a 5 alpha reductase that works predominantly in the conversion of T to DHT and this is proven by hair loss that otherwise would not happen. Unfortunately, however, its inhibition in the long or short term causes in my opinion a reduction in its ability to transform progesterone into neuro transmitters and reduce cortisol. The effects of this altered function of the 5 alpha reductase are that the DHT is too much for the receptors no longer able to process it correctly and this creates the androgenic blockade with increased conversion of testosterone into estrogen and additional cortisol and this explains the increase in fat and muscle loss. The deficiency of neuro transmitters caused by insufficient conversion of progesterone into allopregnanolone causes depression anxiety muscle tremors and decompensation with dopamine and serotonin. Failure to transform cortisol into less active metabolites increases muscle loss and systemic inflammation. The receptor contributes to the damage because it defends itself against the excessive load of DHT by turning off its activity and this increases estrogen and cortisol as well as oxidized metabolites that the body struggles to dispose of and accumulate. The issue in my opinion is to be able to make up for the deficiencies of 5 alpha reductase that concern the production of neuro transmitters and the reduction of cortisol on the other hand to have a less aggressive production of DHT to allow the receptors to do their job. Here my feeling is that the three main activities of the 5 alpha reductase are basically unbalanced towards the conversion of T into DHT and that this causes all the problems to fall on the body and mind. Now I would like to know if anyone here has hypothesized how to balance the activity of 5 alpha reductase because inhibiting it means less neuro transmitters and therefore depression less reduction of active cortisol and therefore pain and inflammation less DHT that lightens the receptor but that does not allow a functioning of anabolism because the body becomes overwhelmed by cortisol and general depression. So the solution can never reset the 5 alpha reductase but goes through its modulation and balancing in the activities it must carry out or produce neuro transmitters, convert the right amount of T into DHT and cortisol into less active metabolites. We all have basic genetics and we only know because we lose our hair that our 5 alpha reductase is very active in converting T to DHT. Do you have any ideas? I would like to know what you think about it and if you imagine therapeutic hypotheses or have ever heard of a similar reasoning on 5 alpha reductase. Thank you
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