My blood tests

Good hormonal panel. Here is what I think it’s happening:

Your (little) pregnenolone gets converted to DHEA but not to progesterone and to cortisol. Serum cortisol is completely useless, don’t test it. From the other hormones though, we can see that your cortisol is very low: E2 is high because you don’t have cortisol to downregulate T, therefore your body uses E2; RT3 is high because your T4 does not find cortisol to match up, and therefore gets dumped into RT3.

I think you are a perfect candidate for transdermal progesterone (it’s an over-the-counter medication). That will raise your cortisol (and therefore energy). It will also cause a decrease in E2 and RT3. If you try and do not feel any improvement (or if the improvement subsides) the likely reason will be that you ran out of thyroid hormones (which are needed to convert progesterone to cortisol).

I would not use TD pregnenolone in your case, given the preference of your body to redirect pregnenolone towards T. Therefore, if you took pregnenolone, it will likely convert into E2.