Muscle Twitch and Muscle Wastage and Muscle Weakness

[sin]

0. Where are you from (country)?
   JAPAN

1. How did you find this forum (Google search – if so, what search terms? Via link from a forum or website – if so, what page? Other?)
   weblog

2. What is your current age, height, weight?
   age32 height170cm weight72kg

3. Do you excercise regularly? If so, what type of excercise?
   gym every day

4. What type of diet do you eat (vegetarian, meat eater, raw, fast-food/organic healthy)?
   meat eater

5. Why did you take Finasteride (hair loss, BPH, other)?
   hair loss

6. For how long did you take Finasteride (weeks/months/years)?

7. How old were you, and WHEN (date) did you start Finasteride?
   2013-01-10

8. How old were you when you quit, and WHEN (date) did you quit?
   2013-01-17

9. How did you quit (cold turkey or taper off)?
   ED

10. What type of Finasteride did you use – Propecia, Proscar, Fincar or other generic?
    Propecia

11. What dose did you take (eg. 1 mg/day, 1 mg every other day etc.)?
    1 mg/day

12. How long into your use of Finasteride did you notice the onset of side effects?
    1week

13. What side effects did you experience while on the drug that have yet to resolve since discontinuation?

Put an X beside all that apply:

Sexual
[x] Loss of Libido / Sex Drive
[x] Erectile Dysfunction
[ ] Complete Impotence
[x] Loss of Morning Erections
[x] Loss of Spontaneous Erections
[x] Loss of Nocturnal Erections
[x] Watery Ejaculate
[ ] Reduced Ejaculate
[ ] Inability to Ejaculate / Orgasm
[ ] Reduced Sperm Count / Motility

Mental
[ ] Emotional Blunting / Emotionally Flat
[x] Difficulty Focusing / Concentrating
[ ] Confusion
[x] Memory Loss / Forgetfullness
[ ] Stumbling over Words / Losing Train of Thought
[ ] Slurring of Speech
[ ] Lack of Motivation / Feeling Passive / Complacency
[ ] Extreme Anxiety / Panic Attacks
[ ] Severe Depression / Melancholy
[ ] Suicidal Thoughts

Physical
[x] Penile Tissue Changes (narrowing, shrinkage, wrinkled)
[ ] Penis curvature / rotation on axis
[ ] Testicular Pain
[x] Testicular Shrinkage / Loss of Fullness
[ ] Genital numbness / sensitivity decrease
[ ] Weight Gain
[ ] Gynecomastia (male breasts)
[x] Muscle Wastage
[x] Muscle Weakness
[ ] Joint Pain
[ ] Dry / Dark Circles under eyes

Misc
[ ] Prostate pain
[ ] Persistent Fatigue / Exhaustion
[ ] Stomach Pains / Digestion Problems
[ ] Constipation / “Poo Pellets”
[ ] Vision - Acuity Decrease / Blurriness
[ ] Increased hair loss
[ ] Frequent urination
[ ] Lowered body temperature

[x] Other (please explain)
Muscle twitch
dyspnea

14. What (if any) treatments have you undertaken to recover from your side effects since discontinuation of the drug?

15. If you have pre or post-Finasteride bloodtests, what hormonal changes have you encountered since discontinuing the drug (pls post your test results in the “Blood Tests” section and link to them in your post)?

16. Anything not listed in the above questions you’d like to share about your experience with Finasteride?

17. Tell us your story, in your own words, about your Finasteride usage and side effects experienced while on/off the drug.

I’m sorry. I cannot speak English.
It is machine-translated.

I stopped it immediately in around one week after I took fin because erection became weak.
A very strong morning shower happened ten days later.
I was pleased very much then.
Furthermore, it became the ED again when I did it for around one week.
Muscle twitch began at that time in a leg and one, and twitch came to be generated with a whole body soon.
The muscle of the whole body softened after it became PFS.
I believed that it was cured and continued a muscular workout hard.
It was slightly soft, but only the upper body was enlarged by training.
However, I suddenly got thinner from (from PFS approximately two years later) around two months ago.
It is painful to walk now and is hot.
The body which I strengthened by boxing and a gym more than ten years narrowed softly in sequence.
The breathing is much harder, too.
Muscle Twitch and Muscle Wastage and Muscle Weakness, it is dyspnea more.
A symptom such as the ALS totally progresses.
Can you not suppress even the symptom of the muscle?
As well as erection, I have developed into a problem whether could live now.
Please advise it. Yes, please.

[xptriado]

hey we are a few already with muscle twitches. can you fall asleep with these twitches?

have you found relief?

i think this is due to high noradrenaline and is androgen related. have you tried testosterone? alpha blocker tizanidine?

[sin]

Thank you xptriado.
Because I can sleep well from a beginning, as for me, as for sleep disorder, there are none though there are muscle convulsions.
Muscle weakness not to stop is terrible.
Because testosterone is the normal range by the blood test, I do not want to do the testosterone supplement.
I watched people who turned worse in this site.
I have not yet tried tizanidine. The medicine is scary.
In addition, it is the present conditions that the Japanese doctor does not have understanding to PFS at all than other countries.

[xptriado]

Yes everything has potential to make you feel worse.

Japanese traditional medicine cant help you?

I will not try tizanidine i will try clonidine in very low doses, 25microgram one or twice a day. Its very low dosage i am having it compounded at pharmacy.

It will lower catecholamines so i expect muscle convulsion problems to improve and especially sleep.

[Arg1819]

@sin Are you better?

[sin]

I can not do English.
Sorry for the machine translation.
I don’t know how to edit it, so I will post it as it is.
First of all, I apologize for the lack of good news.
It’s been 7 years since I became PFS, and my symptoms are getting worse.

I have had abdominal pain for the past two years.
When I lie down, it becomes a little painful, and when I wake up from sleep, I feel tired and abdominal pain for about 2 hours.
The colon examination and gastrocamera were normal.
Fortunately I have no sleep disorders.
However, when I wake up from sleep, I feel tired and have abdominal pain.
I have no sleep disorders, but I am tired and always want to sleep.
I can sleep well, but I don’t feel refreshed when I wake up.
My muscles are still losing more and more.
When I put my skin on it, it started to dent.
Also, when the skin is placed, the skin quickly turns red.
It takes 10 minutes for the dents and redness to disappear.
The face also suddenly started to age.
The dark circles under the eyes appeared from the left, and two months later, they also appeared on the right.
Around the same time, a large vertical wrinkle was formed on the right side of the face.
The gums of the lower teeth are beginning to melt.
The scrotum and penis are as small as the son of an elementary school student.
The scrotum and penis have shrunk too much and are fused together.
Wrinkles are formed from the base of the penis in the same way as the scrotum, and hair grows.
I hate it because my parents don’t believe it at all.
My mother says “it’s lack of exercise” and “it’s aging”.
I think I’m pretty unhappy among the people in the forums here.
Every time I see myself in the mirror, I remember the movie “the fly”.
I’m sorry to scare you.
My only strength is mental strength.
Being a realist, I have given up on recovery, but I want to leave a lot of money for my wife and children by the time I die.
For that reason, I want to succeed in my work even if I drag my body.

I’m thinking of creating a new topic, but I’m worried that hair loss and sebum won’t stop.
Androgen receptor dysfunction is suspected as one of the causes of PFS.
However, my hair loss and sebum do not stop. Why.
There are too many mysteries.

Thank you for reading to the end.

[Arg1819]

Cómo estás con la erecciones? Yo después del primer año dejé de tener BFS (twitch) fue un año muy difícil. Al parecer el estrés del PFS desencadenó el BFS o es mismo síntoma de propio PFS. Ahora llevo 2 años y un poco más en PFS las erecciones igual de mal. La
Libido cayó en picada.

[guitarman01]

Muscle Biopsy.
Im surprised this test has only been mentioned on here a few times.
I was set to get this at one point but then backed out, I might go ahead and get this done.

This is from one of your members,

“I was operated on a leg, I mean, they cut a piece of muscle to investigate if my cells, exactly, my mitochondrias could breath in good conditions. The Doc confirm a mitochondrial myopathy possibly caused by drugs. However He couldn’t confirmed it was induced by finasteride.”

The most important of these tests is the muscle biopsy , which involves removing a small sample of muscle tissue to examine. When treated with a dye that stains mitochondria , muscles affected by mitochondrial disease often show ragged red fibers — muscle cells (fibers) that have excessive mitochondria .

Diseases - MM - Diagnosis | Muscular Dystrophy Association

](https://www.mda.org/disease/mitochondrial-myopathies/diagnosis#:~:text=The%20most%20important%20of%20these,fibers)%20that%20have%20excessive%20mitochondria.)

Muscle biopsy is useful for the differential diagnosis of immune mediated myopathies, muscular dystrophies, congenital myopathies, and mitochondrial myopathies. With the advent of new molecular studies, muscle biopsy has been necessary to confirm the pathogenicity of new gene variants. In doubtful cases, muscle biopsy may provide the morphologic phenotype necessary for diagnostic confirmation. Due to organ specific mutation load in mitochondriopathies, the muscle tissue may be the only source of representative DNA or RNA samples for molecular diagnosis.

[holyhead]

Mitochondrial myopathy I believe one of the causes in pfs…It is caused by changes in genes which from unpublished rumors finasteride is believed to have affected several genes…

[anon74895881]

@sin

Androgen receptor dysfunction is suspected as one of the causes of PFS.
However, my hair loss and sebum do not stop. Why.

I don’t think Androgen receptors are silenced everywhere in body. I have no hairloss or sebum since pfs, muscles are totally dead, still my erections are somewhat better.

[pete]

On muscle twitches - I have successfully resolved these 100% by taking magnesium daily. Magnesium citrate worked better for me than other forms (glycimate, threonate, etc).

[sin]

arg1819
The erection is weakening.
Viagra is less effective than it was in the early days.
I think this is because the erectile power is lower than the effect of Viagra.
The penis is thin, the veins are prominent, and the skin is shiny.

guitarman01 holyhead
It’s scary to take muscle.
And it’s sad that there is no chance of recovery when it turns out to be mitochondrial disease.

FinDestroyedMe
Does that mean that the androgen receptor responds and does not respond?
I am unhappy that my muscle strength and sexual function decline without being effective against hair loss and sebum.
The beard on the face is very thick.

pete
There was a time when I was taking magnesium, but it didn’t work for me.
Also, even if the spasms disappear, there is no point in losing the muscles.

Thank you for your reply.

[anon74895881]

Androgen receptors are dead at places where ur tissues were totally dependent on androgens like the muscles and penis, but ur scalp hair might not be totally dependent on it !

My muscles are totally dead. I feel like i have no muscles in my body, only bones. This poison has effected me very severely physically.

Have u tried any powerful androgens like proviron, masteron??

[Exsexgod]

Androgen receptors are dead at places where ur tissues were totally dependent on androgens like the muscles and penis,
… sometimes I think the First Pill on this demented night was allrady a kind of suicide.

[basementdweller]

I went through the same thing for over a year. I slowly improved from trt + hcg. My gut used to not tolerate creatine but now I can take a low dose. Creatine has been helping immensely. I suggest looking into it if you haven’t already.

[Exsexgod]

So @guitarman01 what should WE do?! mitochondrial myopathie, muscle athropy, androgen receptors hypersensible, androgen receptor genes silenced, brainfog, fatigue, ED, los libido, no feelings anymore. No Sex Drive, No Drive to get out of the bed, No Chance for Recovery? Enjoying a Basic Zombie Live?

[anon74895881]

U can’t draw any conclusions unless u post ur blood tests here. What if u are a hypogonad and just need a trt?

[Exsexgod]

@anon74895881 This ist my latste Hope. God let me be only hypogonad. Doctor gives me TRT and hCG and everything will be fine again. My TRT from the urologist has been extremly low. But Up to now this shit has all ready destroyed my future. It killed my biggest love.

[anon74895881]

Take the free Testosterone test as well. Some stupid doctors just see total Testosterone and claim that u are totally fine, free Testosterone is more important.

[Exsexgod]

On 7 of June I’m going to visit a specialist for the second time, to talk about my blood Analysis. And to get a Therapy Suggestion.