Mianserin reversed numb genitals and brain fog

Therapeutic Efforts Pharmaceutical
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#3

I have and still taking it. 60 mg gives curved erections and a lots of sweating, like working too strong. 30 doesn’t give sweatings and curved erections but the problem while on 30 sleep is worse but without it had been much worse. What I noticed is a more enriched lifestyle with 30 mg mianserin makes that I can feel the blood rushing through my brain. It’s very promising because the beardgrowth speed comes back and other symptoms reverses nearly completely then like insomnia and the natural sleepy feeling like before and libido. I believe this medicine can have the possibility to clean up a lot but I would recommend to not begin from less than 30 if you give it a try. Not lower and not higher than 37,5 due to my own reactions and readings and have some patience. But its pretty limited data on this… I am going from now to have a more active lifestyle with work (I have been quite house bound and unemployed after the crash) because it’s necessary to have some people around and stimulate the brain if the medicine should have a fair chance to do it’s work I have noted.

It doesn’t give weight gain for me like mirtazapin. From my experience mianserin seems to start brain cleaning and mirtazapin only threat symptoms

I’m actually very surpriced i haven’t seen more users of this medicine.

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#4

it helps your brain fog too?

but gives you bad sleep?

#5

I don’t feel brainfog is a part of my pfs .

I meant sleep is worse on 30 mg than 60. But 60 is too high, for me atleast.

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#6

My word. Very very best of luck to you there and please please keep logging and updating! :slight_smile:

How long have you been taking it?

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#7

Please keep posting

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#8

The above post showed a small study of 17 men with libido loss during SSRI treatment in which 15/17 improved sexual symptoms with Mianserin at low doses of 7.5-15 mg for three months. Seems like hopeful data! As always, I suggest caution and I am not recommending you all go popping this stuff. Just reporting the data.

On the other hand, if you look online, people have tried this stuff to cure their PSSD and got mostly disappointing results from what I see.

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#9

These men didn’t have PSSD though, they were still taking SSRI.

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#10

Thanks

Actually one year but one mistake is that I have exercised the first 10 months. When i paid attention to it it seemed to prevent what mianserin builded up, like libido and exercising gave me too low blood pressure… Walks since two months and it seem to be better. waiting on my work to take place on Tuesday. Hopefully improvement with this combined. Libido is better on 30 than the higher dosage I had before

Regarding the study I readed a thread on pssdforum some time. Them who took like 10 mg hadn’t success or hurt themselves. Higher doses like 45 to 60 didn’t seem too promising in the long run. And many failed to report dosage. So we don’t have many trials on the most interesting dosage 30 mg which Louis who cured himself (according to himself). The dosage is very important! And not an indoor unenriched environment lifestyle.

Take care so long☺

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#11

Mianserin appears to exert its effects via antagonism of histamine and serotonin receptors, and inhibition of norepinephrine reuptake. … As an H1 receptor inverse agonist with high affinity, mianserin has strong antihistamine effects (e.g., sedation).

There also seems to be a strong relationship with histamine and sweat production.
This older class of antidepressants (tetracyclic) were strong h1 receptor antagonists.
There could be some type of rebound effect with histamine as well.

#12

Shouldnt we still be cautious of mianserin/ mirtazapine causing depletion of androgens via the many fold increase in 3a-HSD akin to SSRIs? I wonder if this mechanism is no more than theoretical guesswork espoused on this forum or if its actually been demonstrated in studies.

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#13

I don’t know about mianserin but mirtazapine and ssri raising 3a-hsd has been in lots of studies.

#14

I know that it does. But please point me to literature that shows it leads to rapid depletion of androgenic substrates and thus to PSSD.

#15

How is it going fr you???

#16

Never heard of such study, probably just theoratical guessing.
Doesn’t makes sense to me anyway cause post mianserin/ mirtazapine cases aren’t really a thing.

#17

Though apparently rare, It does happen. There is a user on this forum, @Dtch, who only used Mirtazapine

#18

Hi everybody. I havent used internet in these months. Feel like it makes me worse.

No exercising, taking the tablet a bit later (9:45 instead of 8:30 in evening) makes it working like it should. Horribly unnecessarily mistake to take it so early Before.
Ive improved pretty much the latest days, especially since i threated teeth inflammation (sideffect from mianserin?) Now i have to hold my teets clean! This is important anyway for health overall.
I dont understand this attitude wait and see and be careful. Maybe it hurts me in some way like 3Ahdiol receptor 5diol agonist… I dont care.
Im looking on what happens while on ths drug. Im sleeping in the nights and even some naps in the day like before and the libido has gone up. Memory is great and premature ejaculation is gone.
I have to weight in what i get
I have been very deep into this s so where should i be otherwize?
Im no way cured but i recognize myself much more

Its important to pay attention to what makes the medicine to work with and not against you. For example it works much better if im socialising and fill the time with something (not computer). Even maturbating once in the morning makes it working better. And like i said taking it same time a bit later was a good trick for me

#19

Hello, I am looking forward to the side effects of propecie (finasteride). I am currently taking welbutrin and mianserine just for sleep. How much time have you started to sleep better after taking this nominserine? Buoy, I have been taking these 30mg daily for 18 days and then sleeping badly. Regards

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#20

I sleeped better when i took them a bit later in evening. It can even be the combination wellbutrin and mianserin which is wrong. If youre sleep is worse after 18 days i believe its a bad sign. I would taper but ask the doctor how to do.
i may have sounded a bit optimistic in my post. Ive had some bad sides lately like my gut didnt keep the food and i became very hungry. I am now tapering it and replace it with risperidone very low dose.

I even have to point out i had to avoid dht inhibiting food while on this. Maybe a member here had right when he indicated it blocks some dht. The same sensitivity while on mirtazapine.

So is it a good drug this? It has increased my libido and gave me a great memory but like i said it was pretty difficult to let it work with me and not against me. I couldnt for example standing up longer times while on it because the combination strangely gave me curved erections. Even bleeding gums. Many sides i endured to sleep and to eliminate pfs symptoms.

One thing i dont really like on this page is people try a lots of therapies but when it comes to psychiatric drugs people dont touch them. I know there are a bad knowledge about pfs and many doctors dont understand you but there are doctors who understands the pattern and seems to have a good idea to fix the imbalances. Its my opinion but i believe in this much more than going towards hormones directly.

I have even gone through ect and i believe im on a better road than before even if i had some difficult sides.
For now im on 20 mg mianserin and in a switching process to very lowe dose risperidone (0,5 mg). Should work like an antidepressants in this dosage and two weeks in im not disappointed.

So my advice is to try to find a good psychiatric doctors but it can take some time to find the right ones

#21

Thanks for sharing your experiences @fixit. Could you please also take the survey? It’s very important for all of us.

#22

I understand the importance and will take the survey when i have a computer.

Ive thought more about why grombrutus slept worse when started with mianserin. I can talk about myself and too high dopamine levels seems to prevent mianserins effect. Ive came around this problem with one pill quetiapin 25 mg which decrease dopamine when it happens. You take wellbutrin and this increase dopamine so i would really choose one of them. But tapering and not ditching pills is important. Ditching seems to cause pfs